米诺环素对产肺炎克雷伯菌碳青霉烯酶（KPC）的肠杆菌科临床分离株的活性，并与多西环素和替加环素作比较。
Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline.
作者信息
Chen Alice, Smith Kenneth P, Whitfield Betsy A, Zucchi Paola C, Lasco Todd M, Bias Tiffany E, Kirby James E, Hirsch Elizabeth B
机构信息
Northeastern University, Boston, MA, USA.
Beth Israel Deaconess Medical Center, Boston, MA, USA.
出版信息
Diagn Microbiol Infect Dis. 2017 Aug;88(4):365-367. doi: 10.1016/j.diagmicrobio.2017.05.004. Epub 2017 May 11.
We examined the in vitro activity of minocycline against 103 Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae isolates and found approximately half had susceptible (26%) or intermediate (26%) MICs. For a subset of 35 isolates, susceptibility was highest to tigecycline (71% FDA vs. 20% EUCAST) followed by minocycline (14%) and then doxycycline (6%).
我们检测了米诺环素对103株产肺炎克雷伯菌碳青霉烯酶（KPC）的肠杆菌科分离株的体外活性，发现约一半菌株的最低抑菌浓度（MIC）为敏感（26%）或中介（26%）。对于35株分离株的一个子集，对替加环素的敏感性最高（美国食品药品监督管理局标准为71%，欧洲抗菌药物敏感性试验委员会标准为20%），其次是米诺环素（14%），然后是多西环素（6%）。
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