Chen Alice, Smith Kenneth P, Whitfield Betsy A, Zucchi Paola C, Lasco Todd M, Bias Tiffany E, Kirby James E, Hirsch Elizabeth B
Northeastern University, Boston, MA, USA.
Beth Israel Deaconess Medical Center, Boston, MA, USA.
Diagn Microbiol Infect Dis. 2017 Aug;88(4):365-367. doi: 10.1016/j.diagmicrobio.2017.05.004. Epub 2017 May 11.
We examined the in vitro activity of minocycline against 103 Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae isolates and found approximately half had susceptible (26%) or intermediate (26%) MICs. For a subset of 35 isolates, susceptibility was highest to tigecycline (71% FDA vs. 20% EUCAST) followed by minocycline (14%) and then doxycycline (6%).
我们检测了米诺环素对103株产肺炎克雷伯菌碳青霉烯酶（KPC）的肠杆菌科分离株的体外活性，发现约一半菌株的最低抑菌浓度（MIC）为敏感（26%）或中介（26%）。对于35株分离株的一个子集，对替加环素的敏感性最高（美国食品药品监督管理局标准为71%，欧洲抗菌药物敏感性试验委员会标准为20%），其次是米诺环素（14%），然后是多西环素（6%）。
