Department of Psychosomatic Medicine and Psychotherapy, University of Tübingen, Germany; MEG Centre, University Hospital Tübingen, Germany; Graduate Training Center of Neuroscience, IMPRS for Cognitive and Systems Neuroscience, Tübingen, Germany.
MEG Centre, University Hospital Tübingen, Germany; CIMeC, Center for Mind/Brain Sciences, University of Trento, Italy.
Neurosci Biobehav Rev. 2017 Sep;80:80-88. doi: 10.1016/j.neubiorev.2017.05.012. Epub 2017 May 21.
The Cyberball paradigm is often used to study social stress by exclusion/rejection. We aimed to review the existing neuroimaging literatures in order to provide an overview of the neurophysiological mechanisms of social exclusion.
Literature search was conducted to identify neurophysiological studies that investigated effects of social exclusion on neural activity using the Cyberball game and the relevant influential factors on these effects.
In total, 42 studies using different neuroimaging methods were considered. Regions of the insula, anterior cingulate cortex, temporal and prefrontal cortex were activated to social exclusion. These neural activities were pronounced at latencies ranging from 200 to 400ms, and between 400 and 900ms. Influential factors were identified and categorized as intrinsic and extrinsic factors.
An integrated framework describing neural activities under social exclusion in terms of both, temporal and spatial processes is provided. Furthermore, the summary of influential intrinsic and extrinsic factors may help us to understand the diversity of the processes and may guide clinical therapy of stress related disorders.
Cyberball 范式常用于通过排斥/拒绝来研究社会压力。本研究旨在综述现有的神经影像学文献，以提供对社会排斥的神经生理机制的概述。
进行文献检索，以确定使用 Cyberball 游戏研究社会排斥对神经活动影响的神经生理学研究，以及对这些影响有影响的相关因素。
共考虑了 42 项使用不同神经影像学方法的研究。在社会排斥中，岛叶、前扣带回皮质、颞叶和前额叶区域被激活。这些神经活动在 200 到 400ms 之间以及 400 到 900ms 之间的潜伏期内明显。确定了有影响的因素，并将其分为内在和外在因素。
提供了一个综合的框架，从时间和空间过程两个方面描述了社会排斥下的神经活动。此外，内在和外在有影响因素的总结可以帮助我们理解这些过程的多样性，并可能指导与压力相关的疾病的临床治疗。
