Tsuji S, Murai Y, Yarita M
Department of Neurology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Ann Neurol. 1988 Oct;24(4):568-73. doi: 10.1002/ana.410240414.
Cortical somatosensory evoked potentials (SEPs) were studied by noninvasive magnetic stimulation at T-10, T-12, and L-5 vertebral levels and in mid-gluteus muscle and ankle in 27 normal subjects and 7 patients with neurological diseases. Cortical components P2 and N2 were recorded in all normal subjects. The mean peak latencies of P2 were 20.3 +/- 0.9 (standard deviation), 21.1 +/- 1.2, 23.5 +/- 1.4, 27.9 +/- 2.0, and 38.1 +/- 1.8 msec at the T-10, T-12, L-5, midgluteal and ankle sites of stimulation, respectively. No substantial difference in morphology of P2 and N2 was seen between magnetic and electrical stimulation at T-12. Amplitudes of P2 and N2 were maximal after magnetic stimulation at motor threshold. P2 and N2 may originate from the sensory cortex. P2 and N2 evoked by T-10 and T-12 stimulation were normal in peak latency and morphology in patients with polyneuropathy or polyradiculoneuropathy. Peak latencies of P2 and N2 evoked by T-10 and T-12 stimulation were significantly delayed in patients with myelopathy. The patients with radiculopathy showed a delayed peak latency and conduction time of P2 evoked by L-5 stimulation. Magnetic stimulation of spinal root is able to detect lesions of spinal cord noninvasively.
对27名正常受试者和7名患有神经系统疾病的患者，通过在T - 10、T - 12和L - 5椎体水平以及臀中肌和踝关节处进行非侵入性磁刺激来研究皮质体感诱发电位（SEP）。在所有正常受试者中均记录到皮质成分P2和N2。在T - 10、T - 12、L - 5、臀中肌和踝关节刺激部位，P2的平均峰潜伏期分别为20.3±0.9（标准差）、21.1±1.2、23.5±1.4、27.9±2.0和38.1±1.8毫秒。在T - 12处，磁刺激和电刺激之间P2和N2的形态没有明显差异。在运动阈值进行磁刺激后，P2和N2的波幅最大。P2和N2可能起源于感觉皮层。在患有多发性神经病或多神经根神经病的患者中，由T - 10和T - 12刺激诱发的P2和N2在峰潜伏期和形态上是正常的。在患有脊髓病的患者中，由T - 10和T - 12刺激诱发的P2和N2的峰潜伏期明显延迟。患有神经根病的患者在L - 5刺激诱发的P2的峰潜伏期和传导时间延迟。脊髓神经根的磁刺激能够非侵入性地检测脊髓病变。
