Duke Joseph W, Elliott Jonathan E, Laurie Steven S, Voelkel Thomas, Gladstone Igor M, Fish Mathews B, Lovering Andrew T
Northern Arizona University, Department of Biological Sciences, Flagstaff, AZ, USA.
University of Oregon, Department of Human Physiology, Eugene, OR, USA.
Respir Physiol Neurobiol. 2017 Sep;243:47-54. doi: 10.1016/j.resp.2017.05.006. Epub 2017 May 20.
Several methods exist to study intrapulmonary arteriovenous anastomoses (IPAVA) in humans. Transthoracic saline contrast echocardiography (TTSCE), i.e., bubble scores, is minimally-invasive, but cannot be used to quantify the magnitude of blood flow through IPAVA (Q). Radiolabeled macroaggregates of albumin (Tc-MAA) have been used to quantify Q in humans, but this requires injection of radioactive particles. Previous work has shown agreement between Tc-MAA and TTSCE, but this has not been tested simultaneously in the same group of subjects. Thus, the purpose of this study was to determine if there was a relationship between Q quantified with Tc-MAA and bubble scores obtained with TTSCE. To test this, we used Tc-MAA and TTSCE to quantify and detect Q at rest and during exercise in humans. Q significantly increased from rest to exercise using Tc-MAA and TTSCE and there was a moderately-strong, but significant relationship between methods. Our data suggest that high bubble scores generally correspond with large Q quantified with Tc-MAA during exercise.
有几种方法可用于研究人体肺内动静脉吻合（IPAVA）。经胸盐水对比超声心动图（TTSCE），即气泡评分，是微创的，但不能用于量化通过IPAVA的血流量（Q）。放射性标记的白蛋白大聚合体（Tc-MAA）已被用于量化人体的Q，但这需要注射放射性颗粒。先前的研究表明Tc-MAA和TTSCE之间具有一致性，但尚未在同一组受试者中同时进行测试。因此，本研究的目的是确定用Tc-MAA量化的Q与用TTSCE获得的气泡评分之间是否存在关系。为了验证这一点，我们使用Tc-MAA和TTSCE在人体静息和运动时量化并检测Q。使用Tc-MAA和TTSCE时，Q从静息到运动时显著增加，并且两种方法之间存在中等强度但显著的关系。我们的数据表明，在运动期间，高气泡评分通常与用Tc-MAA量化的大Q相对应。
