对《耐受性胰岛素肽疗法引发1型糖尿病》的回复
Reply to "Tolerogenic insulin peptide therapy precipitates type 1 diabetes".
作者信息
Daniel Carolin, Weigmann Benno, von Boehmer Harald
机构信息
Institute for Diabetes Research, Research Group Immune Tolerance in Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, Munich, Germany
Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany.
出版信息
J Exp Med. 2017 Jul 3;214(7):2157-2159. doi: 10.1084/jem.20170285. Epub 2017 May 23.
Abstract
In this issue of JEM, Bergman et al. (https://doi.org/10.1084/jem.20160471) challenge the data published in our previous JEM paper on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Here, we provide a response to these data and suggest that appropriate subimmunogenic conditions are required to induce Foxp3 regulatory T cell conversion.
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Reply to "Tolerogenic insulin peptide therapy precipitates type 1 diabetes".对《耐受性胰岛素肽疗法引发1型糖尿病》的回复
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本文引用的文献
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Tolerogenic insulin peptide therapy precipitates type 1 diabetes.耐受性胰岛素肽疗法会引发1型糖尿病。
J Exp Med. 2017 Jul 3;214(7):2153-2156. doi: 10.1084/jem.20160471. Epub 2017 May 23.
2
Immunotherapy for Type 1 Diabetes: Why Do Current Protocols Not Halt the Underlying Disease Process?1 型糖尿病的免疫疗法：为何现行方案无法阻止潜在疾病进程？
Cell Metab. 2017 Feb 7;25(2):233-241. doi: 10.1016/j.cmet.2016.10.009. Epub 2016 Nov 10.
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Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells.肠道微生物群通过促进派尔集合淋巴结T滤泡辅助细胞的分化和迁移来驱动自身免疫性关节炎。
Immunity. 2016 Apr 19;44(4):875-88. doi: 10.1016/j.immuni.2016.03.013.
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The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes.非肥胖糖尿病（NOD）小鼠模型在自身免疫性糖尿病中的重要性。
J Autoimmun. 2016 Jan;66:76-88. doi: 10.1016/j.jaut.2015.08.019. Epub 2015 Sep 26.
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Immunotherapies and immune biomarkers in Type 1 diabetes: A partnership for success.免疫疗法和 1 型糖尿病的免疫生物标志物：成功的伙伴关系。
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