Pavanello Sofia, Stendardo Mariarita, Mastrangelo Giuseppe, Bonci Melissa, Bottazzi Barbara, Campisi Manuela, Nardini Marco, Leone Roberto, Mantovani Alberto, Boschetto Piera
Occupational Medicine, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Front Immunol. 2017 May 9;8:516. doi: 10.3389/fimmu.2017.00516. eCollection 2017.
Aging is an emerging worldwide threat to public health, even in the workplace, as it links with risk of illness and death. Bewildered inflammatory responses and stressful conditions associate with age-related disorders. Additionally, circadian rhythm disruption, a critical health issue in night-shift workers, correlates with premature aging. We investigated the hypothesis of a link between altered inflammatory response, detected by plasmatic long pentraxin 3 (PTX3), and biological aging, measured by leukocyte telomere length (LTL), attrition, and possibly induced by night-shift work. Within the framework of a cross-sectional study, such possible relationships were appraised by simultaneous equation model (SEM) technique among day and night-shift hospital workers. PTX3 levels, modulated by several aging conditions [i.e., body mass index (BMI) (beta = -0.22; = 0.022), C-reactive protein (CRP) (beta = -0.07; = 0.000), and cardiovascular diseases with hypertension included (CVD) (beta = -0.12; = 0.000)], positively associate with LTL (coefficient = 0.15; = 0.033). LTL, in turn is reduced by CVD (beta = -0.15; = 0.000), binge drinking (beta = -0.10; = 0.004), and CRP (beta = -0.05; = 0.026). On the other hand, night-shift work, found to be remarkably free from aging risk factors [i.e., age (beta = -0.13; = 0.017), BMI (beta = -0.17; = 0.030), CVD (beta = -0.14; = 0.000), and binge drinking (beta = -0.13; = 0.000)], does associate almost significantly with reversed PTX3 (coefficient = -0.09; = 0.089) and even with CRP (beta = 0.17; = 0.000). In conclusion, the SEM analysis indicates that PTX3 is positively linked to LTL. The finding suggests a possible new role of this long pentraxin that, by orchestrating an efficient governance of inflammatory processes, may protect telomere from attrition, ensuring therefore the genetic stability of cells. The higher CRP levels among night-shift workers suggest that night-shift work is associated with increased systemic inflammation. This would make nocturnal workers more susceptible to premature aging.
衰老正成为全球公共卫生领域一个新出现的威胁，即便在工作场所也是如此，因为它与患病和死亡风险相关联。令人困惑的炎症反应和压力状况与年龄相关疾病有关。此外，昼夜节律紊乱是夜班工作者面临的一个关键健康问题，与早衰相关。我们研究了一个假设，即通过血浆长五聚体蛋白3（PTX3）检测到的炎症反应改变与通过白细胞端粒长度（LTL）测量的生物衰老之间存在联系，LTL缩短可能由夜班工作引起。在一项横断面研究的框架内，通过联立方程模型（SEM）技术评估了日班和夜班医院工作人员之间的这种可能关系。PTX3水平受多种衰老条件调节[即体重指数（BMI）（β = -0.22；P = 0.022）、C反应蛋白（CRP）（β = -0.07；P = 0.000）以及包括高血压在内的心血管疾病（CVD）（β = -0.12；P = 0.000）]，与LTL呈正相关（系数 = 0.15；P = 0.033）。反过来，CVD（β = -0.15；P = 0.000）、暴饮（β = -0.10；P = 0.004）和CRP（β = -0.05；P = 0.026）会使LTL缩短。另一方面，发现夜班工作显著没有衰老风险因素[即年龄（β = -0.13；P = 0.017）、BMI（β = -0.17；P = 0.030）、CVD（β = -0.14；P = 0.000）和暴饮（β = -0.13；P = 0.000）]，但确实几乎显著地与PTX3反向相关（系数 = -0.09；P = 0.089），甚至与CRP相关（β = 0.17；P = 0.000）。总之，SEM分析表明PTX3与LTL呈正相关。这一发现提示了这种长五聚体蛋白可能具有的新作用，即通过协调对炎症过程的有效调控，可能保护端粒不被损耗，从而确保细胞的遗传稳定性。夜班工作者中较高的CRP水平表明夜班工作与全身炎症增加有关。这会使夜间工作者更容易早衰。
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