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通过ERK1/2丝裂原活化蛋白激酶信号通路抑制平滑肌细胞增殖。

inhibits smooth muscle cell proliferation via the ERK1/2 MAPK signaling pathway.

作者信息

Jin Enze, Han Seongho, Son Mina, Kim Sung-Whan

机构信息

Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.

Department of Family Medicine, College of Medicine, Dong-A University, Busan, Republic of Korea.

出版信息

Cell Mol Biol Lett. 2016 Oct 21;21:24. doi: 10.1186/s11658-016-0023-z. eCollection 2016.

DOI:10.1186/s11658-016-0023-z
PMID:28536626
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5415766/
Abstract

belongs to a genus of acormycete fungi and is known to exhibit various pharmacological effects. The aim of this study was to investigate the effect of species on the proliferation of vascular smooth muscle cells (VSMC) and their underlying molecular mechanism. A cell proliferation assay showed that ethanol extract (CBEE) significantly inhibited VSMC proliferation. In addition, neointimal formation was significantly reduced by treatment with CBEE in the carotid artery of balloon-injured rats. We also investigated the effects of CBEE on the extracellular signal-regulated kinase (ERK) signal pathway. Western blot analysis revealed increased ERK 1/2 phosphorylation in VSMCs treated with CBEE. Pretreatment with U0126 completely abrogated CBEE-induced ERK 1/2 phosphorylation. In conclusion, CBEE exhibited anti-proliferative properties that affected VSMCs through the ERK1/2 MAPK signaling pathway. Our data may elucidate the inhibitory mechanism of this natural product

摘要

属于子囊菌纲真菌属，已知具有多种药理作用。本研究的目的是研究该物种对血管平滑肌细胞（VSMC）增殖的影响及其潜在分子机制。细胞增殖试验表明，乙醇提取物（CBEE）显著抑制VSMC增殖。此外，在球囊损伤大鼠的颈动脉中，CBEE治疗显著减少了新生内膜的形成。我们还研究了CBEE对细胞外信号调节激酶（ERK）信号通路的影响。蛋白质印迹分析显示，用CBEE处理的VSMC中ERK 1/2磷酸化增加。用U0126预处理完全消除了CBEE诱导的ERK 1/2磷酸化。总之，CBEE表现出抗增殖特性，通过ERK1/2 MAPK信号通路影响VSMC。我们的数据可能阐明了这种天然产物的抑制机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126c/5415766/d1fad6512689/11658_2016_23_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126c/5415766/598567d36ab1/11658_2016_23_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126c/5415766/edf35a2865d6/11658_2016_23_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126c/5415766/3a34338f3026/11658_2016_23_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126c/5415766/68e1b85b32f0/11658_2016_23_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126c/5415766/d1fad6512689/11658_2016_23_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126c/5415766/598567d36ab1/11658_2016_23_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126c/5415766/edf35a2865d6/11658_2016_23_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126c/5415766/3a34338f3026/11658_2016_23_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126c/5415766/68e1b85b32f0/11658_2016_23_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/126c/5415766/d1fad6512689/11658_2016_23_Fig5_HTML.jpg

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