Chung Wei-Sheng, Lin Cheng-Li
Wei-Sheng Chung, MD, PhD, Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan, No. 199, Section 1, San-Min Road, Taichung City 40343, Taiwan, Tel.: +886 4 22294411, Fax: +886 4 22290020, E-mail:
Thromb Haemost. 2017 Jul 26;117(8):1637-1643. doi: 10.1160/TH17-01-0039. Epub 2017 May 24.
Systemic inflammation and hypercoagulability in psoriasis are related to cardiovascular morbidity. The aim of the study was to investigate the incidence and risk of venous thromboembolism (VTE) in patients with psoriasis in Taiwan. We identified inpatients aged ≥ 18 years with a diagnosis of psoriasis and controls at a 1: 1 ratio of frequency matched by sex, age, frequency of medical visits, length of stay, and comorbidities between 2000 and 2010 in the Taiwan National Health Insurance Research Database. Each patient was traced to the date of VTE occurrence, loss to follow-up, death, or the December 31, 2011, whichever occurred first. We analysed 8945 patients with psoriasis and 8945 controls. The patients with psoriasis exhibited a greater incidence rate of VTE (19.2 vs 9.88 per 10 000 person-years) than did the controls. After adjustment for covariates, the patients with psoriasis presented a 2.02-fold risk of VTE (adjusted hazard ratio [aHR] = 2.02, 95 % confidence interval [CI] = 1.42-2.88) compared with that in the control cohort. The aHR of VTE was significantly higher in the first year of follow-up (aHR = 3.30, 95 % CI = 1.45-7.55) than after one year (aHR = 1.68, 95 % CI = 1.13-2.49).
银屑病中的全身炎症和高凝状态与心血管疾病发病率相关。本研究旨在调查台湾银屑病患者静脉血栓栓塞（VTE）的发生率和风险。我们在台湾国民健康保险研究数据库中，按照性别、年龄、就诊频率、住院时间和合并症将2000年至2010年期间年龄≥18岁、诊断为银屑病的住院患者与对照组以1:1的频率匹配比例进行识别。每位患者被追踪至VTE发生日期、失访、死亡或2011年12月31日，以先发生者为准。我们分析了8945例银屑病患者和8945例对照。银屑病患者的VTE发生率（每10000人年19.2例 vs 9.88例）高于对照组。在对协变量进行调整后，银屑病患者发生VTE的风险是对照组的2.02倍（调整后风险比[aHR]=2.02，95%置信区间[CI]=1.42 - 2.88）。随访第一年VTE的aHR显著高于一年后（aHR = 3.30，95% CI = 1.45 - 7.55）（aHR = 1.68，95% CI = 1.13 - 2.49）。
