Fernandez D, Bolli P, Snedden W, Vasdev S, Fernandez P G
Department of Medicine, Memorial University Medical School, St John's Newfoundland, Canada.
J Hypertens Suppl. 1988 Dec;6(4):S145-7. doi: 10.1097/00004872-198812040-00042.
The interactions of blood pressure, salt intake and angiotensin converting enzyme (ACE) inhibition were investigated in the Dahl salt-sensitive (DS) and salt-resistant (DR) strains of rats. Eight-week-old DS and DR (40 of each) were separately randomized to receive a low- (0.4% NaCl) or a high- (8% NaCl) salt diet for 3 weeks. Thereafter the rats were further separated randomly to receive the ACE inhibitor lisinopril (3-8 mg/kg per day) or no drug treatment for 11 weeks. In untreated DS rats blood pressure rose, paralleled by a higher left ventricular mass (ratio left ventricular weight/body weight) irrespective of salt intake. Lisinopril lowered blood pressure to normotensive levels in all groups except DS rats on a high-salt diet, despite doses of up to 100 mg/kg per day, although there was a significant fall in blood pressure. Lisinopril reduced left ventricular mass significantly on the low- but not on the high-salt diet. Plasma renin activity increased on lisinopril treatment in all groups except DS rats on the high-salt diet. Regression of an increased left ventricular mass by ACE inhibition seemed to be impaired by a high salt intake, even when blood pressure was lowered. Therefore, although for regression of left ventricular hypertrophy, reduction of afterload was the leading factor, this might be adversely affected by a high salt intake.
在Dahl盐敏感（DS）和盐抵抗（DR）大鼠品系中研究了血压、盐摄入量与血管紧张素转换酶（ACE）抑制之间的相互作用。将8周龄的DS和DR大鼠（各40只）分别随机分为低（0.4% NaCl）盐饮食组或高（8% NaCl）盐饮食组，持续3周。此后，将大鼠进一步随机分组，分别接受ACE抑制剂赖诺普利（每天3 - 8 mg/kg）或不接受药物治疗，持续11周。在未治疗的DS大鼠中，无论盐摄入量如何，血压都会升高，同时左心室质量增加（左心室重量/体重比值）。赖诺普利可使除高盐饮食的DS大鼠外的所有组血压降至正常水平，尽管给予高达每天100 mg/kg的剂量时血压仍有显著下降。赖诺普利在低盐饮食时可显著降低左心室质量，但在高盐饮食时则无此作用。除高盐饮食的DS大鼠外，所有组在接受赖诺普利治疗后血浆肾素活性均升高。即使血压降低，高盐摄入似乎也会损害ACE抑制对增加的左心室质量的逆转作用。因此，尽管对于左心室肥厚的逆转，降低后负荷是主要因素，但高盐摄入可能会对其产生不利影响。
