5-亚苄基-4-恶唑烷酮能有效抑制耐甲氧西林金黄色葡萄球菌生物膜的形成。
5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus.
作者信息
Edwards Grant A, Shymanska Nataliia V, Pierce Joshua G
机构信息
Department of Chemistry, NC State University, 2620 Yarbrough Drive, Raleigh, NC 27695, USA.
出版信息
Chem Commun (Camb). 2017 Jun 29;53(53):7353-7356. doi: 10.1039/c7cc03626d.
Abstract
Investigation into the biological function of 5-benzylidene-4-oxazolidinones revealed dose-dependent inhibition of biofilm formation in Methicillin-resistant S. aureus (MRSA). This structurally unusual class of small molecules inhibit up to 89% of biofilm formation with IC values as low as 0.78 μM, and disperse pre-formed biofilms with IC values as low as 4.7 μM. Together, these results suggest that 4-oxazolidinones represent new chemotypes to enable the study of bacterial biofilms with small molecule chemical probes.
摘要
对5-亚苄基-4-恶唑烷酮的生物学功能研究表明，其对耐甲氧西林金黄色葡萄球菌（MRSA）生物膜形成具有剂量依赖性抑制作用。这类结构独特的小分子对生物膜形成的抑制率高达89%，IC值低至0.78 μM，对已形成的生物膜的分散作用IC值低至4.7 μM。这些结果共同表明，4-恶唑烷酮代表了新的化学类型，可用小分子化学探针来研究细菌生物膜。
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