Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil.
Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília, Brasília, Brazil.
Front Cell Infect Microbiol. 2019 Apr 2;9:74. doi: 10.3389/fcimb.2019.00074. eCollection 2019.
Antimicrobial resistance constitutes one of the major challenges facing humanity in the Twenty-First century. The spread of resistant pathogens has been such that the possibility of returning to a pre-antibiotic era is real. In this scenario, innovative therapeutic strategies must be employed to restrict resistance. Among the innovative proposed strategies, anti-virulence therapy has been envisioned as a promising alternative for effective control of the emergence and spread of resistant pathogens. This review presents some of the anti-virulence strategies that are currently being developed, it will cover strategies focused on quench pathogen quorum sensing (QS) systems, disassemble of bacterial functional membrane microdomains (FMMs), disruption of biofilm formation and bacterial toxin neutralization.
抗微生物药物耐药性是 21 世纪人类面临的主要挑战之一。耐药病原体的传播已经使得回到抗生素前时代的可能性成为现实。在这种情况下，必须采用创新的治疗策略来限制耐药性。在提出的创新策略中，抗毒力治疗被认为是有效控制耐药病原体出现和传播的一种有前途的替代方法。本综述介绍了目前正在开发的一些抗毒力策略，将涵盖针对抑制病原体群体感应 (QS) 系统、破坏细菌功能膜微区 (FMM)、干扰生物膜形成和中和细菌毒素的策略。
