Delva P, Devynck M A, Degan M, Pernollet M G, Capra C, Meyer P, Lechi A
Clinica Medica, University of Verona, Italy.
J Hypertens Suppl. 1988 Dec;6(4):S348-50. doi: 10.1097/00004872-198812040-00108.
It has been postulated that one or more plasma digitalis-like compounds may play an important role in body fluid regulation and in essential hypertension, although very little is known about their possible role in general haemodynamics. We therefore measured plasma inhibition of human kidney Na+,K+-ATPase and plasma cross-reactivity with digoxin antibodies in 11 normotensive cardiopathic subjects admitted to our clinic for heart catheterization. Possible correlations with haemodynamic parameters were studied. Plasma digoxin-like activity correlated directly with left atrial pressure and with pulmonary circulation data. The ability of the plasma to inhibit Na+,K+-ATPase showed an inverse correlation with cardiac output and cardiac index. No correlations were found with any of the other parameters measured, notably systemic resistance, blood pressure and natriuresis. These findings suggest the presence of more than one substance sharing chemical properties with digitalis: (1) a substance cross-reacting with digoxin antibodies and dependent on pulmonary vascular congestion; and (2) a substance capable of inhibiting the Na+-K+ pump and present in large amounts in heart diseases with a reduced cardiac index.
据推测，一种或多种血浆洋地黄样化合物可能在体液调节和原发性高血压中发挥重要作用，尽管对其在一般血液动力学中的可能作用知之甚少。因此，我们对11名因心脏导管插入术入住我们诊所的血压正常的心脏病患者，测量了血浆对人肾Na +，K + -ATP酶的抑制作用以及血浆与地高辛抗体的交叉反应性。研究了与血液动力学参数的可能相关性。血浆地高辛样活性与左心房压力和肺循环数据直接相关。血浆抑制Na +，K + -ATP酶的能力与心输出量和心脏指数呈负相关。未发现与所测量的任何其他参数相关，特别是全身阻力、血压和利钠作用。这些发现表明存在一种以上与洋地黄具有共同化学性质的物质：（1）一种与地高辛抗体发生交叉反应且依赖于肺血管充血的物质；（2）一种能够抑制Na + -K +泵且在心脏指数降低的心脏病中大量存在的物质。
