Michel M C, Daul A, Galal O, Wang X L, Brodde O E
Medical Klinik and Poliklinik, University of Essen, FRG.
J Hypertens Suppl. 1988 Dec;6(4):S575-7. doi: 10.1097/00004872-198812040-00180.
In order to find out whether adrenoceptor changes in essential hypertension might be genetically determined, we measured platelet alpha 2- and lymphocyte beta 2-adrenoceptor density in 48 normotensive children with normotensive parents, and 41 normotensive children who had one essential hypertensive parent and thus should have had a genetic predisposition for the development of hypertension. The groups did not differ with regard to blood pressure and heart rate, age, body weight and height, plasma renin activity and catecholamines, and serum electrolytes and creatinine. Lymphocyte beta 2-adrenoceptor density (assessed by 125I-iodocyanopindolol binding) and responsiveness (assessed as 10 mumol/l isoprenaline-induced cyclic AMP increases) did not differ between the groups. Platelet alpha 2-adrenoceptor density (assessed by 3H-yohimbine binding) was significantly higher in children with one essential hypertensive parent. We conclude that platelet alpha 2- but not lymphocyte beta 2-adrenoceptor changes in essential hypertension are genetically determined.
为了弄清楚原发性高血压患者的肾上腺素能受体变化是否由基因决定，我们测定了48名父母血压正常的血压正常儿童以及41名父母一方患有原发性高血压因而应该有高血压发病遗传易感性的血压正常儿童的血小板α₂ - 肾上腺素能受体密度和淋巴细胞β₂ - 肾上腺素能受体密度。两组在血压、心率、年龄、体重、身高、血浆肾素活性、儿茶酚胺、血清电解质和肌酐方面并无差异。两组间淋巴细胞β₂ - 肾上腺素能受体密度（通过¹²⁵I - 碘氰吲哚洛尔结合法评估）和反应性（通过10μmol/L异丙肾上腺素诱导的环磷酸腺苷增加来评估）并无差异。父母一方患有原发性高血压的儿童的血小板α₂ - 肾上腺素能受体密度（通过³H - 育亨宾结合法评估）显著更高。我们得出结论，原发性高血压中血小板α₂ - 而非淋巴细胞β₂ - 肾上腺素能受体变化是由基因决定的。
