Graafsma S J, Lenders J W, Peters J H, van Tits L J, Pieters G F, Rodrigues de Miranda J F, Thien T
Department of Internal Medicine, University of Nijmegen, The Netherlands.
J Hypertens Suppl. 1988 Dec;6(4):S578-80. doi: 10.1097/00004872-198812040-00181.
The effect of mental arithmetic on beta 2-adrenoceptors on lymphocytes, as measured by (-)125I-iodocyanopindolol binding, was studied in normotensive and essential hypertensive females. To determine the role of adrenaline, mental arithmetic was also carried out in bilaterally adrenalectomized females. There were no significant differences in the blood pressure and heart rate responses to mental arithmetic among the three groups. Baseline values or changes in adrenaline levels during mental arithmetic were similar in normotensives and hypertensives, whereas levels of adrenaline remained undetectable throughout the test in adrenalectomized females. Baseline values of beta 2-adrenoceptors did not differ among the three groups. In normotensive and hypertensive females the increase in beta 2-adrenoceptor density was, respectively, 27 and 20%. Baseline values of beta 2-adrenoceptors were not related to the percentage changes in the receptor densities. In adrenalectomized females, in contrast to normotensives and hypertensives, there was no change in receptor density. These findings suggest that adrenaline plays a role in the short-term upregulation of beta 2-adrenoceptors after mental arithmetic.
通过（-）125I-碘氰吲哚洛尔结合法测量，研究了心算对正常血压和原发性高血压女性淋巴细胞β2-肾上腺素能受体的影响。为了确定肾上腺素的作用，还对双侧肾上腺切除的女性进行了心算。三组之间对心算的血压和心率反应无显著差异。正常血压者和高血压者在心算期间的肾上腺素基线值或变化相似，而在肾上腺切除的女性中，整个测试过程中肾上腺素水平均未检测到。三组之间β2-肾上腺素能受体的基线值无差异。在正常血压和高血压女性中，β2-肾上腺素能受体密度分别增加了27%和20%。β2-肾上腺素能受体的基线值与受体密度的百分比变化无关。与正常血压者和高血压者相比，肾上腺切除的女性受体密度没有变化。这些发现表明，肾上腺素在心算后β2-肾上腺素能受体的短期上调中起作用。
