子宫切除术与左炔诺孕酮宫内节育系统治疗异常子宫出血的疗效比较及对健康相关生活质量的影响。
Comparative effectiveness and impact on health-related quality of life of hysterectomy vs. levonorgestrel intra-uterine system for abnormal uterine bleeding.
机构信息
Department of Medical and Surgical Science and Translation Medicine, Sant'Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
出版信息
Eur Rev Med Pharmacol Sci. 2017 May;21(9):2255-2260.
OBJECTIVE
To compare hysterectomy and levonorgestrel intra-uterine system (LNG-IUS) for the treatment of abnormal uterine bleeding (AUB) and iron deficiency anemia.
PATIENTS AND METHODS
Retrospective study evaluating quality of life, sexual function, satisfaction and blood hemoglobin concentration improvement in 60 pre-menopausal women treated with hysterectomy or LNG-IUS. All analysis was performed with statistical software SPSS 21.0 (SPSS Inc., Chicago, IL, USA).
RESULTS
Despite superior control of bleeding and dysmenorrhea observed after hysterectomy, LNG-IUS showed similar impact on blood hemoglobin levels, quality of life, satisfaction and sexual function resulting more cost-effective.
CONCLUSIONS
In the absence of contraindications, LNG-IUS should always be the first therapeutic choice for chronic AUB. Surgical treatment must be considered as an "extrema ratio".
目的
比较子宫切除术和左炔诺孕酮宫内节育系统（LNG-IUS）治疗异常子宫出血（AUB）和缺铁性贫血的效果。
患者与方法
回顾性研究评估了 60 例接受子宫切除术或 LNG-IUS 治疗的围绝经期妇女的生活质量、性功能、满意度和血血红蛋白浓度改善情况。所有分析均使用 SPSS 21.0 统计软件（SPSS Inc.，芝加哥，IL，美国）进行。
结果
尽管子宫切除术后出血和痛经得到了更好的控制，但 LNG-IUS 对血血红蛋白水平、生活质量、满意度和性功能的影响相似，且更具成本效益。
结论
在没有禁忌症的情况下，LNG-IUS 应始终是慢性 AUB 的首选治疗方法。手术治疗必须被视为“极端选择”。
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