血清 miR-4262 的上调预示急性髓系白血病患者的临床结局。

Up-regulation of serum miR-4262 predicts clinical outcome of patients with acute myeloid leukemia.

机构信息

First Clinical Medical College of Nanchang University, Nanchang, Jiangxi, China.

出版信息

Eur Rev Med Pharmacol Sci. 2017 May;21(9):2172-2176.

Abstract

OBJECTIVE

The aim of this study was to investigate whether miR-4262 was associated with the prognosis of acute myeloid leukemia (AML) patients.

PATIENTS AND METHODS

Serum and bone marrow miR-4262 expression were investigated in 186 AML patients and 115 healthy normal controls by using Real-time PCR. Associations between miR-4262 expressions and various clinicopathological characteristics were analyzed. Overall survival and relapse-free survival were evaluated using the Kaplan-Meier method. Univariate and multivariate analysis were performed using the Cox proportional hazard analysis.

RESULTS

Expression levels of miR-4262 in the bone marrow and serum of AML patients were both significantly higher than those in healthy controls (both p<0.01). Moreover, increased miR-4262 expression was significantly associated with FAB classification (p=0.001) and cytogenetics (p=0.001). Patients with high miR-4262 expression had poorer overall survival time and relapse-free survival time than those with low miR-4262 expression. Finally, multivariate analysis identified high miR-4262 expression as an independent prognostic factor for AML (p<0.001).

CONCLUSIONS

Our data revealed that the evaluation of miR-4262 expression in the bone marrow and serum was an ideal tool for predicting the progression of AML and prognosis.

摘要

目的

本研究旨在探讨 miR-4262 是否与急性髓系白血病（AML）患者的预后相关。

方法

采用 Real-time PCR 检测 186 例 AML 患者和 115 例健康正常对照者的血清和骨髓 miR-4262 表达。分析 miR-4262 表达与各种临床病理特征之间的关系。采用 Kaplan-Meier 法评估总生存时间和无病生存时间。采用 Cox 比例风险分析进行单因素和多因素分析。

结果

AML 患者骨髓和血清中 miR-4262 的表达水平均明显高于健康对照组（均 p<0.01）。此外，miR-4262 表达增加与 FAB 分类（p=0.001）和细胞遗传学（p=0.001）显著相关。高 miR-4262 表达组患者的总生存时间和无病生存时间均明显短于低 miR-4262 表达组。最后，多因素分析确定高 miR-4262 表达是 AML 的独立预后因素（p<0.001）。