沙特阿拉伯利雅得地区阿拉伯马驹体内蛔虫属寄生虫驱虫抗性的实地研究。

A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia.

作者信息

Alanazi Abdullah D, Mukbel Rami M, Alyousif Mohamed S, AlShehri Zafer S, Alanazi Ibrahim O, Al-Mohammed Hamdan I

机构信息

a Department of Biological Science, Faculty of Science and Humanities , Shaqra University , Ad-Dawadimi , Saudi Arabia.

b Department of Basic Veterinary Medical Sciences, Faculty of Veterinary Medicine , Jordan University of Science and Technology , Irbid , Jordan.

出版信息

Vet Q. 2017 Dec;37(1):200-205. doi: 10.1080/01652176.2017.1334981.

DOI:10.1080/01652176.2017.1334981

PMID:28537782

Abstract

BACKGROUND

In the last decade, Parascaris spp. resistance to anthelmintics has been recorded in many countries. In Saudi Arabia, there are limited data available on Parascaris spp. resistance to anthelmintics.

OBJECTIVE

To determine the current status of ivermectin, abamectin and praziquantel combined, and fenbendazole resistance to Parascaris spp. in horses in Saudi Arabia.

METHODS

Three hundred and forty-one foals from eleven different farms were examined by faecal egg count (FEC). The foals were all Arab horses aged 17.2 ± 4.5 (SD) months. Ivermectin (n = 46 foals), abamectin and praziquantel combined (n = 46), and fenbendazole (n = 46) were administered on day 0 and faeces were collected on day 14. The study comprised 41 untreated foals as controls. Animals that have FEC of ≥100 eggs per gram (EPG) were used to measure anthelmintic efficacy. Parascaris spp. populations were considered susceptible when faecal egg count reduction (FECR) was ≥95% associated with a lower 95% confidence limit (LCL) >90%, suspected resistant when FECR ≤90% or LCL <90% and resistant when FECR <90% and LCL <90%.

RESULTS

Prevalence of Parascaris spp. infection was 53% (179/341 horses). Anthelmintic resistance to Parascaris spp. were highest following fenbendazole (55% of farms and 65% of foals) and to a lower extent following ivermectin or the combination of abamectin and praziquantel which comprised 27% of farms (and 46% of foals) and 18% of farms (and 10% of foals), respectively.

CONCLUSION

These data indicate that anthelmintics-resistant Parascaris spp. populations are present on horse farms in Saudi Arabia.

摘要

背景

在过去十年中，许多国家都记录到了副蛔虫属对驱虫药产生抗药性的情况。在沙特阿拉伯，关于副蛔虫属对驱虫药抗药性的数据有限。

目的

确定伊维菌素、阿维菌素与吡喹酮联用以及芬苯达唑对沙特阿拉伯马匹体内副蛔虫属的抗药性现状。

方法

对来自11个不同农场的341匹幼驹进行粪便虫卵计数（FEC）检查。这些幼驹均为阿拉伯马，年龄为17.2±4.5（标准差）个月。在第0天给予伊维菌素（46匹幼驹）、阿维菌素与吡喹酮联用药物（46匹）以及芬苯达唑（46匹），并在第14天收集粪便。该研究包括41匹未治疗的幼驹作为对照。粪便虫卵计数≥100个/克（EPG）的动物用于测量驱虫药疗效。当粪便虫卵计数减少率（FECR）≥95%且较低的95%置信下限（LCL）>90%时，副蛔虫属种群被认为敏感；当FECR≤90%或LCL<90%时，被怀疑有抗药性；当FECR<90%且LCL<90%时，则被认为有抗药性。