Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.
Department of Chemistry, Pohang University of Science and Technology , Pohang 37673, Republic of Korea.
J Am Chem Soc. 2017 Jun 7;139(22):7432-7435. doi: 10.1021/jacs.7b02708. Epub 2017 May 26.
We report here a synthetic ion channel developed from a shape-persistent porphyrin-based covalent organic cage. The cage was synthesized by employing a synthetically economical dynamic covalent chemistry (DCC) approach. The organic cage selectively transports biologically relevant iodide ions over other inorganic anions by a dehydration-driven, channel mechanism as evidenced by vesicle-based fluorescence assays and planar lipid bilayer-based single channel recordings. Furthermore, the organic cage appears to facilitate iodide transport across the membrane of a living cell, suggesting that the cage could be useful as a biological tool that may replace defective iodide channels in living systems.
我们在此报告一种由形状稳定的基于卟啉的共价有机笼合成的人工离子通道。该笼采用合成经济的动态共价化学（DCC）方法合成。基于囊泡的荧光测定和平面脂质双层的单通道记录实验表明，该有机笼通过脱水驱动的通道机制选择性地转运生物相关的碘离子，而不是其他无机阴离子。此外，该有机笼似乎有助于碘离子穿过活细胞的膜进行转运，这表明该笼可用作生物工具，可能替代活系统中功能缺陷的碘离子通道。
