Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
Retina. 2018 Jun;38(6):1091-1099. doi: 10.1097/IAE.0000000000001709.
To evaluate parafoveal microvasculature in eyes with circumscribed choroidal hemangioma using optical coherence tomography angiography.
Fourteen eyes with unilateral circumscribed choroidal hemangioma were imaged using OCT for central macular thickness and optical coherence tomography angiography for superficial and deep foveal avascular zone area, and superficial and deep capillary density (CD), comparing affected and paired fellow eyes.
Mean patient age was 53 years, and mean visual acuity was 20/60 in the involved eye and 20/25 in the fellow eye. In the affected eye, clinical findings included cystoid macular edema (CME) in 1, parafoveal/subfoveal subretinal fluid (SRF) in three, and both CME and SRF in two eyes. OCT revealed current CME/SRF in six eyes, and normal foveal contour in eight eyes, among which five never demonstrated OCT evidence of CME or SRF. By OCT (affected vs. fellow eye), mean central macular thickness was greater in affected eyes (312 vs. 264 μm, P = 0.042). By optical coherence tomography angiography, there was no difference in superficial foveal avascular zone (P = 0.327), deep foveal avascular zone (P = 0.563), and superficial CD (P = 0.159), but mean deep plexus CD was reduced in affected eyes (50% vs. 54%, P = 0.010). Subgroup analysis showed that eyes with previous or current CME and/or SRF had reduced deep plexus CD (53% vs. 57%, P = 0.005), while eyes without previous/current CME/SRF had similar deep plexus CD (P = 0.399) compared with fellow eyes.
Circumscribed choroidal hemangioma generally does not affect parafoveal inner retinal microvasculature. However, a reduction in deep plexus CD can be expected in eyes with previous or current CME/SRF.
使用光相干断层扫描血管造影术评估局限性脉络膜血管瘤周边的脉络膜微脉管系统。
对 14 只单侧局限性脉络膜血管瘤的眼睛进行中心视网膜厚度的光相干断层扫描和浅层及深层黄斑无血管区面积、浅层及深层毛细血管密度（CD）的光相干断层扫描血管造影检查，将病变眼与对侧正常眼进行比较。
患者平均年龄为 53 岁，受累眼的平均视力为 20/60，对侧眼的平均视力为 20/25。在受影响的眼中，临床发现包括 1 只眼中存在囊样黄斑水肿（CME），3 只眼中存在黄斑下/sub 黄斑下视网膜下液（SRF），2 只眼中同时存在 CME 和 SRF。OCT 显示 6 只眼中存在当前的 CME/SRF，8 只眼中存在正常的黄斑中心凹轮廓，其中 5 只眼从未出现 OCT 证据表明存在 CME 或 SRF。OCT（受影响的眼与对侧眼）显示，受影响的眼中黄斑中心厚度更大（312μm 对 264μm，P=0.042）。通过光相干断层扫描血管造影，浅层黄斑无血管区（P=0.327）、深层黄斑无血管区（P=0.563）和浅层 CD（P=0.159）无差异，但受影响的眼中深层丛 CD 减少（50%对 54%，P=0.010）。亚组分析显示，存在先前或当前 CME 和/或 SRF 的眼，深层丛 CD 减少（53%对 57%，P=0.005），而无先前/当前 CME/SRF 的眼，与对侧眼相比，深层丛 CD 相似（P=0.399）。
局限性脉络膜血管瘤一般不会影响周边黄斑内层视网膜的微血管系统。然而，先前或当前 CME/SRF 的眼可能会出现深层丛 CD 减少。
