Robinson D R, Tateno S, Patel B, Hirai A
Department of Medicine, Massachusetts General Hospital, Boston.
Prog Clin Biol Res. 1988;282:295-303.
Dietary marine lipids reduce both mortality and the severity of glomerulonephritis in inbred murine strains which develop spontaneous autoimmune disease. The protective effects of marine lipids appears to be accounted for by the major n-3 fatty acids in these preparations, 20:5 and 22:6. The n-3 fatty acids in dietary fish oil are extensively incorporated into several lipid classes in the spleen of autoimmune mice, including phosphatidylinositol, phosphatidylethanolamine, plasmalogens and saturated ether-linked phospholipids as well as diacylphosphoglycerides. The effects of dietary marine lipids on autoimmune disease in experimental models are highly specific. Careful controlled trials will be required to establish the role of dietary marine lipids in the therapy of human autoimmune disease.
膳食海洋脂质可降低患有自发性自身免疫性疾病的近交系小鼠品系的死亡率和肾小球肾炎的严重程度。海洋脂质的保护作用似乎是由这些制剂中的主要n-3脂肪酸（20:5和22:6）所致。膳食鱼油中的n-3脂肪酸被广泛整合到自身免疫小鼠脾脏中的几种脂质类别中，包括磷脂酰肌醇、磷脂酰乙醇胺、缩醛磷脂和饱和醚连接磷脂以及二酰基磷酸甘油酯。膳食海洋脂质在实验模型中对自身免疫性疾病的影响具有高度特异性。需要进行仔细对照试验来确定膳食海洋脂质在人类自身免疫性疾病治疗中的作用。
