Orenstein Lauren Av, Micheletti Robert G
Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA.
Departments of Dermatology and Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA.
Semin Cutan Med Surg. 2017 Jun;36(2):62-66. doi: 10.12788/j.sder.2017.021.
Hidradenitis suppurativa is a chronic inflammatory disease of the folliculo-infundibular unit for which no individual treatment is uniformly effective. A wide array of therapies has been reported successful in the treatment of hidradenitis, although few high-quality clinical trials have been conducted. Comparing the effectiveness of different therapies has proven challenging due to heterogeneity and limited validation of outcome measures. We performed a systematic review of clinical trials of medical treatments for hidradenitis, yielding 8 articles reporting on 9 trials of antibiotic, hormonal, and biologic therapies. In addition, we discuss existing observational data on commonly used therapeutic regimens, as well as the outcome measures driving clinical research in hidradenitis suppurativa.
化脓性汗腺炎是一种毛囊漏斗部单位的慢性炎症性疾病，尚无单一治疗方法能普遍有效。尽管进行的高质量临床试验较少，但已有大量治疗方法被报道成功用于治疗化脓性汗腺炎。由于异质性和结局指标验证有限，比较不同治疗方法的有效性已被证明具有挑战性。我们对化脓性汗腺炎药物治疗的临床试验进行了系统评价，得出8篇文章，报道了9项抗生素、激素和生物治疗试验。此外，我们还讨论了常用治疗方案的现有观察数据，以及推动化脓性汗腺炎临床研究的结局指标。
