沙特代谢综合征患者中胃饥饿素水平与动脉僵硬度标志物及炎症标志物之间的关联。

The association between ghrelin levels and markers of arterial stiffness and inflammatory markers in Saudi subjects with metabolic syndrome.

作者信息

Ali Tarek Mohamed, Mehanna Osama Mahmoud, El Askary Ahmad

机构信息

Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Saudi Arabia & Department of Medical Physiology, Faculty of medicine, Beni-Suef University, Egypt.

Department of Medical Physiology, Faculty of medicine, Taif University, Saudi Arabia & Department of Medical Physiology, Faculty of medicine, Al-Azhar University, Egypt.

出版信息

Diabetes Metab Syndr. 2017 Dec;11 Suppl 2:S721-S725. doi: 10.1016/j.dsx.2017.05.005. Epub 2017 May 12.

DOI:10.1016/j.dsx.2017.05.005

PMID:28539201

Abstract

BACKGROUND

Arterial stiffness is a principal cardiovascular risk factor. Metabolic syndrome (MetS) is a predisposing factor to arterial stiffness and persistent MetS circumstances can deteriorate the arterial stiffness severity. Low concentrations of plasma ghrelin are meticulously connected to arterial stiffness. This work targeted to judge the relationship between plasma ghrelin levels and intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) as markers of arterial stiffness and inflammatory markers and in Saudi subjects with MetS.

PATIENTS AND METHODS

Eighty-four young adults were recruited from the visitors of the outpatient clinics of Taif hospitals, and then they were divided into a control group that involves subjects without MetS and a study group involving those with MetS. Anthropometric measurements, blood pressure, plasma ghrelin levels, fasting plasma glucose levels (FPG) and lipid profile were assessed. baPWV was measured by a volume plethysmograph while IMT was evaluated by ultrasonography.

RESULTS

Plasma ghrelin values were significantly (P<0.001) decreased in the MetS group versus control group. Arterial stiffness was noticed in MetS group by significantly (P<0.01) increased IMT and baPWV (P<0.001) matched with control group. Plasma ghrelin concentrations were negatively associated with age, smoking, FPG, HbA1c, CRP, TNF-alpha, baPWV, and Lt Carotid IMT.

CONCLUSIONS

Depending on our outcomes showing the valuable properties of ghrelin in the cardiovascular system in patients with metabolic syndrome, it can be postulated that ghrelin may be associated with markers of atherosclerosis.

摘要

背景

动脉僵硬度是主要的心血管危险因素。代谢综合征（MetS）是动脉僵硬度的一个诱发因素，持续的MetS情况会使动脉僵硬度严重程度恶化。血浆胃饥饿素浓度低与动脉僵硬度密切相关。这项研究旨在判断沙特患有MetS的受试者中，血浆胃饥饿素水平与作为动脉僵硬度标志物的内膜中层厚度（IMT）和臂踝脉搏波速度（baPWV）以及炎症标志物之间的关系。

患者与方法

从塔伊夫医院门诊的就诊者中招募了84名年轻人，然后将他们分为一个不患有MetS的对照组和一个患有MetS的研究组。评估了人体测量学指标、血压、血浆胃饥饿素水平、空腹血糖水平（FPG）和血脂谱。通过容积脉搏描记仪测量baPWV，同时通过超声检查评估IMT。

结果

与对照组相比，MetS组的血浆胃饥饿素值显著降低（P<0.001）。MetS组出现动脉僵硬度，与对照组相比，IMT显著增加（P<0.01），baPWV显著增加（P<0.001）。血浆胃饥饿素浓度与年龄、吸烟、FPG、糖化血红蛋白（HbA1c）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、baPWV和左颈动脉IMT呈负相关。