Graduate Program in Pathology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), RS, Brazil.
Graduate Program in Pathology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), RS, Brazil; Human Genetics, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), RS, Brazil; Graduate Program in Biosciences, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), RS, Brazil.
Int J Cardiol. 2017 Sep 15;243:194-196. doi: 10.1016/j.ijcard.2017.05.078. Epub 2017 May 18.
There are few studies assessing the birth measures of patients with congenital heart disease (CHD). Our aim to evaluate their progression and impact over the outcome.
The cases consisted of patients with CHD during their first hospitalization in a reference cardiac and pediatric intensive care unit (ICU) from Southern Brazil. Controls were composed of patients with no clinical evidence of CHD hospitalized soon after cases. The cases underwent high-resolution karyotype and fluorescence in situ hybridization (FISH) for 22q11 microdeletion. We analyzed birth weight, length and head circumference of patients of both groups. For CHD patients, we evaluated their progression and impact until hospitalization at ICU.
Our sample was composed of 198 cases and controls. We observe a difference in birth weight of CHD patients only in relation to general population. There was a significant increase in children with CHD and weight below the lower limit from birth until the hospitalization at ICU, and this occurred more in those without complex CHD. Syndromic patients and with an extracardiac malformation also presented a greater difficulty to maintain not only the weight but also the length/height until the hospitalization. Individuals with weight below the lower limit at hospitalization who died had a tendency to present longer stay at ICU.
Some CHD patients, especially without complex defects, and with syndromic aspect and a major extracardiac malformation, present a higher difficult to maintain their weight and growth, and, therefore, may be at risk and should be more closely monitored.
评估先天性心脏病（CHD）患者出生指标的研究较少。我们旨在评估这些指标的进展及其对结局的影响。
该病例组纳入了在巴西南部某心脏和儿科重症监护病房（ICU）首次住院的 CHD 患者，对照组由无 CHD 临床证据的患者组成，这些患者在病例组之后不久住院。对病例组进行了高分辨率核型分析和 22q11 微缺失荧光原位杂交（FISH）检测。我们分析了两组患者的出生体重、身长和头围。对于 CHD 患者，我们评估了他们在 ICU 住院前的进展和影响。
我们的样本包括 198 例病例和对照组。我们仅观察到 CHD 患者的出生体重与一般人群存在差异。患有 CHD 且体重低于出生时下限的儿童在直至 ICU 住院期间体重显著增加，而无复杂 CHD 的儿童更为明显。综合征患儿和伴发心脏外畸形的患儿在维持体重和身高方面也存在更大的困难。在 ICU 住院时体重低于下限且死亡的患者在 ICU 的住院时间往往更长。
一些 CHD 患者，尤其是无复杂缺陷、伴有综合征表现和严重心脏外畸形的患者，在维持体重和生长方面存在更高的困难，因此可能存在风险，应更密切地监测。
