Taylor Marcus K, Padilla Genieleah A, Hernández Lisa M
Biobehavioral Sciences Lab, Warfighter Performance Department, Naval Health Research Center, San Diego, CA, USA; Department of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA, USA; Institute for Interdisciplinary Salivary Bioscience Research, University of California Irvine, Irvine, CA, USA.
Biobehavioral Sciences Lab, Warfighter Performance Department, Naval Health Research Center, San Diego, CA, USA.
Steroids. 2017 Aug;124:18-22. doi: 10.1016/j.steroids.2017.05.010. Epub 2017 May 21.
We recently established stable daily profiles of the anabolic hormones dehydroepiandrosterone (DHEA) and testosterone in 57 elite military men. In this follow-on study, we explored associations of salivary anabolic hormone profiles with demographic (i.e., age, body mass index [BMI]) and biobehavioral health indices (i.e., blood pressure, sleep, perceived stress, fatigue) via correlational models. Next, nuanced patterns were constructed using quartile splits followed by one-way analysis of variance and post hoc subgroup comparisons. Both DHEA (r range: -0.33 to -0.49) and testosterone (r range: -0.19 to -0.41) were inversely associated with age. Quartile comparisons revealed that age-related declines in DHEA were linear, curvilinear, or sigmoidal, depending on the summary parameter of interest. Anabolic hormone profiles did not associate with BMI, blood pressure, or sleep efficiency. Robust linear associations were observed between testosterone and perceived stress (r range: -0.29 to -0.36); concentration-dependent patterns were less discernible. Lower DHEA (r range: -0.22 to -0.30) and testosterone (r range: -0.22 to -0.36) concentrations associated with higher fatigue. Subsequent quartile comparisons suggested a concentration-dependent threshold with respect to evening testosterone. Specifically, those individuals within the lowest quartile (≤68.4pg/mL) endorsed the highest fatigue of the four groups (p=0.01), while the remaining three groups did not differ from each other. This study not only showed that anabolic hormone profiles have distinctive age trajectories, but are also valuable predictors of stress and fatigue in elite military men. This highlights the importance of routine monitoring of anabolic hormone profiles to sustain and optimize health and readiness in chronically stressed populations.
我们最近建立了57名精英军人合成代谢激素脱氢表雄酮（DHEA）和睾酮的稳定每日变化曲线。在这项后续研究中，我们通过相关模型探讨了唾液合成代谢激素变化曲线与人口统计学指标（即年龄、体重指数[BMI]）以及生物行为健康指标（即血压、睡眠、感知压力、疲劳）之间的关联。接下来，使用四分位数分割构建细微模式，随后进行单因素方差分析和事后亚组比较。DHEA（r范围：-0.33至-0.49）和睾酮（r范围：-0.19至-0.41）均与年龄呈负相关。四分位数比较显示，DHEA与年龄相关的下降呈线性、曲线或S形，具体取决于所关注的汇总参数。合成代谢激素变化曲线与BMI、血压或睡眠效率无关。在睾酮与感知压力之间观察到稳健的线性关联（r范围：-0.29至-0.36）；浓度依赖性模式不太明显。较低的DHEA（r范围：-0.22至-0.30）和睾酮（r范围：-0.22至-0.36）浓度与较高的疲劳相关。随后的四分位数比较表明，夜间睾酮存在浓度依赖性阈值。具体而言，处于最低四分位数（≤68.4pg/mL）的个体在四组中疲劳程度最高（p=0.01），而其余三组之间没有差异。这项研究不仅表明合成代谢激素变化曲线具有独特的年龄轨迹，而且还是精英军人压力和疲劳的重要预测指标。这突出了常规监测合成代谢激素变化曲线对于维持和优化长期处于压力下人群的健康及战备状态的重要性。
