Campisi Roxana, Marengo Fernando D
Department of Nuclear Medicine and Cardiovascular Imaging, Diagnóstico Maipú, Buenos Aires, Argentina.
Department of Nuclear Medicine, Instituto Argentino de Diagnóstico y Tratamiento S.A., Buenos Aires, Argentina.
Cardiovasc Diagn Ther. 2017 Apr;7(2):196-205. doi: 10.21037/cdt.2017.04.08.
Traditional approaches for risk assessment of ischemic heart disease (IHD) are based on the physiological consequences of an epicardial coronary stenosis. Of note, normal coronary arteries or nonobstructive coronary artery disease (CAD) is a common finding in women with signs and symptoms of ischemia. Therefore, assessment of risk based on a coronary stenosis approach may fail in women. Positron emission tomography (PET) quantifies absolute myocardial blood flow (MBF) which may help to elucidate other mechanisms involved such as endothelial dysfunction and alterations in the smooth muscle cell relaxation responsible for IHD in women. The objective of the present review is to describe the current state of the art of PET imaging in assessing IHD in women with nonobstructive CAD.
缺血性心脏病（IHD）风险评估的传统方法基于心外膜冠状动脉狭窄的生理后果。值得注意的是，正常冠状动脉或非阻塞性冠状动脉疾病（CAD）在有缺血症状和体征的女性中很常见。因此，基于冠状动脉狭窄方法的风险评估在女性中可能会失败。正电子发射断层扫描（PET）可量化绝对心肌血流量（MBF），这可能有助于阐明其他相关机制，如内皮功能障碍以及负责女性IHD的平滑肌细胞舒张改变。本综述的目的是描述PET成像在评估非阻塞性CAD女性IHD方面的当前技术水平。
