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本文引用的文献

1
Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.表观遗传小干扰RNA和化学筛选确定SETD8抑制作为高危神经母细胞瘤中p53激活的治疗策略。
Cancer Cell. 2017 Jan 9;31(1):50-63. doi: 10.1016/j.ccell.2016.12.002.
2
Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.赖氨酸甲基转移酶SETD8的选择性底物竞争性抑制剂的发现。
J Med Chem. 2014 Aug 14;57(15):6822-33. doi: 10.1021/jm500871s. Epub 2014 Jul 25.
3
Low p14ARF expression in neuroblastoma cells is associated with repressed histone mark status, and enforced expression induces growth arrest and apoptosis.神经母细胞瘤细胞中低表达 p14ARF 与组蛋白标记状态受抑制有关，强制表达会导致生长停滞和细胞凋亡。
Hum Mol Genet. 2013 May 1;22(9):1735-45. doi: 10.1093/hmg/ddt020. Epub 2013 Jan 23.
4
Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille's heel to be exploited for the therapy of MYCN-amplified neuroblastoma.MYCN 依赖性细胞凋亡和 MDM2-p53 通路的分子机制：神经母细胞瘤中 MYCN 扩增的治疗靶点
Front Oncol. 2012 Oct 12;2:141. doi: 10.3389/fonc.2012.00141. eCollection 2012.
5
Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression.组蛋白赖氨酸甲基转移酶 SETD8 通过调节 PCNA 表达促进肿瘤发生。
Cancer Res. 2012 Jul 1;72(13):3217-27. doi: 10.1158/0008-5472.CAN-11-3701. Epub 2012 May 3.
6
The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1.HMGA1 原癌基因在癌症中经常失调，是 E2F1 的转录靶标。
Mol Carcinog. 2013 Jul;52(7):526-34. doi: 10.1002/mc.21887. Epub 2012 Mar 2.
7
Modulation of p53 function by SET8-mediated methylation at lysine 382.SET8介导的赖氨酸382甲基化对p53功能的调控
Mol Cell. 2007 Aug 17;27(4):636-46. doi: 10.1016/j.molcel.2007.07.012.
8
The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.p53调控基因MDM2是神经母细胞瘤中MYCN的直接转录靶点。
Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):731-6. doi: 10.1073/pnas.0405495102. Epub 2005 Jan 11.

High-SETD8 inactivates p53 in neuroblastoma.

作者信息

Veschi Veronica, Thiele Carol J

机构信息

Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

出版信息

Oncoscience. 2017 Apr 14;4(3-4):21-22. doi: 10.18632/oncoscience.344. eCollection 2017 Mar.

DOI:10.18632/oncoscience.344
PMID:28540329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5441469/
Abstract
摘要