Muranaka M, Monou H, Suzuki J, Lane J D, Anderson N B, Kuhn C M, Schanberg S M, McCown N, Williams R B
Department of Psychosomatic Medicine, Tohoku University School of Medicine.
Health Psychol. 1988;7 Suppl:145-63.
To determine whether there are basic biological differences between Type A and Type B men, we compared hemodynamic, electrophysiologic and neuroendocrine responses to equipotent doses of isoproterenol (ISO) and norepinephrine (NE) in 10 Type A and 10 Type B men ages 18 to 29. Results showed equal hemodynamic and neuroendocrine responses to graded ISO doses in Type A and Type B individuals. In contrast, Type A men showed a more prolonged decrease in electrocardiographic T-wave amplitude (TWA) than did Type B men. Post hoc analyses of the correlates of TWA recovery during high-dose ISO infusion provide preliminary evidence for a more robust parasympathetic antagonism of sympathetic nervous system effects in Type B men, especially those with low scores on the Cook-Medley Ho scale. These findings suggest that, in addition to cognitively mediated increases in sympathetic nervous system reactivity, Type As may also be placed at increased risk of developing coronary heart disease by reduced levels of parasympathetic antagonism of sympathetic effects.
为了确定A型和B型男性之间是否存在基本的生物学差异，我们比较了10名年龄在18至29岁之间的A型男性和10名B型男性对等剂量异丙肾上腺素（ISO）和去甲肾上腺素（NE）的血流动力学、电生理和神经内分泌反应。结果显示，A型和B型个体对不同剂量ISO的血流动力学和神经内分泌反应相同。相比之下，A型男性心电图T波振幅（TWA）的下降时间比B型男性更长。对高剂量ISO输注期间TWA恢复相关性的事后分析为B型男性，尤其是那些在库克-梅德利敌意量表上得分较低的男性，对交感神经系统效应具有更强的副交感神经拮抗作用提供了初步证据。这些发现表明，除了认知介导的交感神经系统反应性增加外，A型男性还可能因交感神经效应的副交感神经拮抗水平降低而增加患冠心病的风险。
