Lasaga M, Duvilanski B H, Seilicovich A, Afione S, Debeljuk L
Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Eur J Pharmacol. 1988 Oct 11;155(1-2):163-6. doi: 10.1016/0014-2999(88)90416-5.
Our data indicate that sex steroids modify the number of GABA receptors, as detected by a [3H]muscimol binding assay, in the tuberoinfundibular GABAergic system. GABA binding was affected by chronic hormonal treatments in different ways depending on the sex of the rats and the steroids administered. Estradiol increased GABA binding in ovariectomized female rats while testosterone decreased the number of GABA binding sites in gonadectomized male rats. These results suggest a sex difference in the regulation of hypothalamic GABA receptors.
我们的数据表明，性类固醇会改变结节漏斗部γ-氨基丁酸（GABA）能系统中通过[3H]蝇蕈醇结合试验检测到的GABA受体数量。GABA结合受到慢性激素处理的不同影响，这取决于大鼠的性别和所施用的类固醇。雌二醇增加了去卵巢雌性大鼠的GABA结合，而睾酮则减少了去势雄性大鼠的GABA结合位点数量。这些结果表明下丘脑GABA受体的调节存在性别差异。
