希腊克里特岛一家大学医院当代肠杆菌分离株的体外药敏和耐药表型

In vitro susceptibility and resistance phenotypes in contemporary Enterobacter isolates in a university hospital in Crete, Greece.

作者信息

Maraki Sofia, Vardakas Konstantinos Z, Samonis George, Perdikis Dimitrios, Mavromanolaki Viktoria Eirini, Kofteridis Diamantis P, Falagas Matthew E

机构信息

Department of Clinical Microbiology, University Hospital of Heraklion, Heraklion, Greece.

Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece.

出版信息

Future Microbiol. 2017 Jun;12:683-693. doi: 10.2217/fmb-2016-0216. Epub 2017 May 25.

DOI:10.2217/fmb-2016-0216

PMID:28540747

Abstract

AIM

To study the evolution in the susceptibility of Enterobacter spp. in Crete, Greece from 2010 to 2015.

METHODS

Non-duplicate isolates were studied using automated systems. Phenotypic confirmatory tests were applied.

RESULTS

A total of 939 Enterobacter isolates were included. Colistin was the most active antibiotic (97.9%) followed by imipenem (96.1%), gentamicin (95.7%), tigecycline (91.8%), cefepime (89.4%), chloramphenicol (85.8%), fosfomycin (85.5%), trimethoprim/sulfamethoxazole (83.3%) and piperacillin/tazobactam (73.3%). Antibiotic resistance did not increase during the study period for most antibiotics. Lower susceptibility was observed among multidrug-resistant strains and carbapenem-nonsusceptible isolates. AmpC was the most common resistant mechanism (21%); carbapenemases (3.7%) and aminoglycoside-modifying enzymes (6.5%) were also detected.

CONCLUSION

A significant proportion of Enterobacter spp. was resistant to several antibiotics, most notably β-lactams.

摘要

目的

研究2010年至2015年希腊克里特岛肠杆菌属细菌的药敏变化情况。

方法

使用自动化系统对非重复分离株进行研究，并应用表型确证试验。

结果

共纳入939株肠杆菌分离株。黏菌素是最有效的抗生素（97.9%），其次是亚胺培南（96.1%）、庆大霉素（95.7%）、替加环素（91.8%）、头孢吡肟（89.4%）、氯霉素（85.8%）、磷霉素（85.5%）、甲氧苄啶/磺胺甲恶唑（83.3%）和哌拉西林/他唑巴坦（73.3%）。在研究期间，大多数抗生素的耐药性并未增加。多重耐药菌株和碳青霉烯不敏感分离株的药敏性较低。AmpC是最常见的耐药机制（21%）；还检测到碳青霉烯酶（3.7%）和氨基糖苷类修饰酶（6.5%）。