白细胞介素-6受体α链（CD126）在意义未明的单克隆丙种球蛋白病和冒烟型骨髓瘤的正常及异常浆细胞中的表达
Expression of the IL-6 receptor alpha-chain (CD126) in normal and abnormal plasma cells in monoclonal gammopathy of undetermined significance and smoldering myeloma.
作者信息
Salem Dalia Abdel-Raouf, Korde Neha, Venzon David J, Liewehr David J, Maric Irina, Calvo Katherine R, Braylan Raul, Tembhare Prashant R, Yuan Constance M, Landgren Carl Ola, Stetler-Stevenson Maryalice
机构信息
a Laboratory of Pathology , CCR, NCI, NIH , Bethesda , MD , USA.
b Department of Clinical Pathology, Faculty of Medicine , Mansoura University , Mansoura , Egypt.
出版信息
Leuk Lymphoma. 2018 Jan;59(1):178-186. doi: 10.1080/10428194.2017.1321746. Epub 2017 May 25.
IL-6 activity in normal plasma cells (nPCs) and abnormal plasma cells (aPCs) is CD126 (subunit of IL-6 receptor) dependent. We quantified CD126 expression on nPCs and aPCs in monoclonal gammopathy of undetermined significance (MGUS), smoldering myeloma (SMM), and multiple myeloma (MM). CD126 was detected on all nPCs and aPCs indicating that CD126 does not have diagnostic utility. CD126 expression was higher in aPCs than in nPCs in 85% SMM but only 41% MGUS and there was evidence that CD126 was higher in aPCs than nPCs in the SMM (p = .048) but not MGUS (p = .96) patients. There is also a greater association between nPC and aPC CD126 expression in low risk MGUS than observed in high risk MGUS and SMM, suggesting normal regulation of CD126 decreases with disease progression. Future studies need to elucidate the role of bone marrow milieu versus escape from normal CD126 regulation in malignant transformation of clonal plasma cells.
正常浆细胞（nPCs）和异常浆细胞（aPCs）中的白细胞介素-6（IL-6）活性依赖于CD126（IL-6受体的亚基）。我们对意义未明的单克隆丙种球蛋白病（MGUS）、冒烟型骨髓瘤（SMM）和多发性骨髓瘤（MM）中的nPCs和aPCs上的CD126表达进行了定量。在所有nPCs和aPCs上均检测到CD126，这表明CD126没有诊断效用。在85%的SMM中，aPCs上的CD126表达高于nPCs，但在MGUS中仅为41%，并且有证据表明在SMM患者中aPCs上的CD126高于nPCs（p = 0.048），但在MGUS患者中并非如此（p = 0.96）。与高风险MGUS和SMM相比，低风险MGUS中nPC和aPC的CD126表达之间的关联也更强，这表明随着疾病进展，CD126的正常调节作用减弱。未来的研究需要阐明骨髓微环境与克隆性浆细胞恶性转化中逃避正常CD126调节的作用。
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