Bollschweiler Elfriede, Plum Patrick, Mönig Stefan P, Hölscher Arnulf H
a Department of General, Visceral and Cancer Surgery , University of Cologne , Köln , Germany.
b Service de Chirurgie viscéral , Hôpitaux Universitaires de Genève , Geneva , Switzerland.
Expert Opin Pharmacother. 2017 Jul;18(10):1001-1010. doi: 10.1080/14656566.2017.1334764. Epub 2017 Jun 7.
Esophageal cancer is the eighth most common cancer globally and has the sixth worst prognosis because of its aggressiveness and poor survival. Data regarding cancer treatment in older patients is limited because the elderly have been under-represented in clinical trials. Therefore, we reviewed the existing literature regarding treatment results for elderly patients (70+ years). Areas covered: We used pubmed to analyze the actual literature according to elderly esophageal cancer patients with subheading of incidence, esophagectomy, chemoradiation or chemotherapy. The main points of interest were treatment options for patients with Barrett's esophagus or early carcinoma, advanced tumor stages, and inoperable cancer. Expert opinion: The incidence of esophageal cancer has been increasing over the past thirty years, with a rapid increase of esophageal adenocarcinoma in Western industrialized nations. Patients aged over 60 years have been particularly affected. In this review, we have shown that elderly patients with esophageal cancer have various alternatives for adequate treatment. Clinical evaluation of comorbidity is necessary to make treatment decisions. Therapeutic options for early carcinomas are endoscopic or surgical resection. For elderly patients with advanced carcinomas, preoperative chemoradiation or chemotherapy should be discussed.
食管癌是全球第八大常见癌症，因其侵袭性和低生存率而成为预后第六差的癌症。由于老年患者在临床试验中的代表性不足，关于老年患者癌症治疗的数据有限。因此，我们回顾了有关老年患者（70岁及以上）治疗结果的现有文献。涵盖领域：我们使用PubMed根据老年食管癌患者的发病率、食管切除术、放化疗或化疗等副标题来分析实际文献。主要关注点是巴雷特食管或早期癌、晚期肿瘤阶段以及无法手术的癌症患者的治疗选择。专家意见：在过去三十年中，食管癌的发病率一直在上升，在西方工业化国家，食管腺癌的发病率迅速增加。60岁以上的患者受影响尤为严重。在本综述中，我们表明老年食管癌患者有多种适当的治疗选择。进行合并症的临床评估对于做出治疗决策很有必要。早期癌的治疗选择是内镜或手术切除。对于老年晚期癌患者，应讨论术前放化疗或化疗。
