Norton C C, Joyner L P
Parasitology. 1978 Dec;77(3):243-8. doi: 10.1017/s0031182000050216.
A line of Eimeria maxima acquired resistance to Lerbek (a mixture of clopidol and methyl benzoquate) after serial passage against rising drug levels. Abnormal bisporocystic oocysts which appeared throughout this series were picked out individually and these produced infections in further groups of chicks. Serial passages of selected bisporocystic forms raised their proportion in oocyst yields to about 80% after 10-14 passages, but a few normal oocysts were still present.
一株巨型艾美耳球虫在连续传代对抗不断升高的药物水平后，获得了对勒贝克（氯羟吡啶和甲基苄喹啉的混合物）的抗性。在这一系列传代过程中出现的异常双孢子囊卵囊被单独挑选出来，并用它们感染更多组雏鸡。对选定的双孢子囊形态进行连续传代后，经过10 - 14代，它们在卵囊产量中的比例提高到了约80%，但仍有一些正常卵囊存在。
