山鸡椒枝中的生物活性糖苷。

Bioactive Glycosides from the Twigs of Litsea cubeba.

机构信息

College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000, People's Republic of China.

出版信息

J Nat Prod. 2017 Jun 23;80(6):1808-1818. doi: 10.1021/acs.jnatprod.6b01189. Epub 2017 May 25.

DOI:10.1021/acs.jnatprod.6b01189

Abstract

The air-dried twigs of Litsea cubeba, a traditional Chinese medicinal tree, afforded 10 new aromatic glycosides (1-10) and 26 known analogues. Their structures were assigned by extensive 1D and 2D NMR experiments, and the absolute configurations were resolved by chemical methods, electronic circular dichroism, specific rotation, and X-ray crystallographic analysis. Compound 4 is the first example of a naturally occurring homoneolignan glucoside. Compounds 4, 6-8, and the known neolignan glucosides (11, 12, and 14) at respective 10 μM concentrations were found to reduce acetaminophen-induced HepG2 cell injury with 30.5-46.0% inhibitions. Furthermore, compounds 12 and 15 demonstrated moderate inhibitory activities against HDAC1, with IC values of 3.6 and 4.6 μM, respectively.

摘要

中国传统药用树木山鸡椒的风干小枝中分离得到 10 个新的芳香性糖苷（1-10）和 26 个已知类似物。通过广泛的 1D 和 2D NMR 实验确定了它们的结构，并通过化学方法、电子圆二色性、比旋光度和 X 射线晶体学分析确定了它们的绝对构型。化合物 4 是第一个天然存在的同型新木脂素葡萄糖苷。在 10 μM 浓度下，化合物 4、6-8 和已知的新木脂素葡萄糖苷（11、12 和 14）分别对乙酰氨基酚诱导的 HepG2 细胞损伤的抑制率为 30.5-46.0%。此外，化合物 12 和 15 对 HDAC1 表现出中等抑制活性，IC 值分别为 3.6 和 4.6 μM。