从山苍子嫩枝中分离得到的两种新的萜类酯苷。
Two new terpenoid ester glycosides from the twigs of Litsea cubeba.
作者信息
Wang Ling-Yan, Tian Ye, Qu Yu-Hong, Wu Yu-Zhuo, Li Yan-Cheng, Li Rui, Lin Peng-Cheng, Shang Xiao-Ya, Lin Sheng
机构信息
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
b National Institutes for Food and Drug Control , Beijing 102629 , China.
出版信息
J Asian Nat Prod Res. 2018 Dec;20(12):1129-1136. doi: 10.1080/10286020.2018.1526789. Epub 2019 Jan 8.
A new sesquiterpenoid ester glycoside (1) and a new monoterpenoid ester glycoside (2) have been isolated from an ethanol extract of the twigs of Litsea cubeba. Their structures were elucidated by extensive 1D- and 2D-NMR experiments, and the absolute configurations were determined by chemical methods, specific rotation, and a combination of experimental and theoretically calculated electronic circular dichroism spectra. Compound 1 exhibited selective cytotoxicity against A549 and HCT-8 cell lines with the IC values of 8.9 and 9.6 μM, respectively.
从山鸡椒嫩枝的乙醇提取物中分离得到了一种新的倍半萜酯苷（1）和一种新的单萜酯苷（2）。通过广泛的一维和二维核磁共振实验阐明了它们的结构，并通过化学方法、比旋光度以及实验和理论计算的电子圆二色光谱相结合的方式确定了绝对构型。化合物1对A549和HCT-8细胞系表现出选择性细胞毒性，其IC值分别为8.9和9.6 μM。
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