Matsuki H, Ozono S, Arai K, Saka M, Cho M, Nakagawa Y, Kaneko Y, Yoshida K, Okamoto S, Maruyama Y
Department of Urology, Nara Medical University.
Hinyokika Kiyo. 1988 Oct;34(10):1757-65.
Thirty-one patients with testicular germ cell tumors were treated in our Department between January, 1979 and June, 1987. Of the 31 patients, 17 (54.8%) had seminoma and 14 (45.2%) had non-seminomatous germ cell tumor (NSGCT) histopathologically. Clinical stage of seminoma was stage I in 13 patients (76.5%) and stage II in 4 patients (23.5%). Clinical stage of NSGCT was stage I in 8 patients (57.2%), stage II in 1 patient (7.1%) and stage III in 5 patients (35.7%). The patients with stage II seminoma underwent high inguinal orchiectomy, radiation therapy, retroperitoneal lymphnode dissection (RPLND) and chemotherapy, and those with stage II and III NSGCT underwent high inguinal orchiectomy and chemotherapy. All patients with stage II seminoma are alive with no evidence of disease. Three patients with stage II and III NSGCT are alive with no evidence of disease, but 3 patients died of the disease. Survival of patients with stage I and II seminoma at 5 years was 100% Survival of stage I and II NSGCT and III NSGCT at 5 years was 100% and 40%, respectively. According to our experience, for patients with advanced seminoma, combination chemotherapy and RPLND as well as radiation therapy are effective. In addition, for patients with advanced NSCGT, adjuvant chemotherapy followed by RPLND is effective.
1979年1月至1987年6月间，我科共治疗了31例睾丸生殖细胞肿瘤患者。31例患者中，组织病理学检查显示17例（54.8%）为精原细胞瘤，14例（45.2%）为非精原细胞性生殖细胞肿瘤（NSGCT）。精原细胞瘤的临床分期为Ⅰ期13例（76.5%），Ⅱ期4例（23.5%）。NSGCT的临床分期为Ⅰ期8例（57.2%），Ⅱ期1例（7.1%），Ⅲ期5例（35.7%）。Ⅱ期精原细胞瘤患者接受了高位腹股沟睾丸切除术、放射治疗、腹膜后淋巴结清扫术（RPLND）和化疗，Ⅱ期和Ⅲ期NSGCT患者接受了高位腹股沟睾丸切除术和化疗。所有Ⅱ期精原细胞瘤患者均存活，无疾病证据。3例Ⅱ期和Ⅲ期NSGCT患者存活，无疾病证据，但3例患者死于该疾病。Ⅰ期和Ⅱ期精原细胞瘤患者5年生存率为100%。Ⅰ期和Ⅱ期NSGCT以及Ⅲ期NSGCT患者5年生存率分别为100%和40%。根据我们的经验，对于晚期精原细胞瘤患者，联合化疗、RPLND以及放射治疗是有效的。此外，对于晚期NSCGT患者，辅助化疗后行RPLND是有效的。
