Pérez-Guijarro Eva, Day Chi-Ping, Merlino Glenn, Zaidi M Raza
Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Cancer. 2017 Jun 1;123(S11):2089-2103. doi: 10.1002/cncr.30684.
Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here, we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma. Cancer 2017;123:2089-103. © 2017 American Cancer Society.
黑色素瘤是一种复杂的疾病,具有高度异质性的病因、组织病理学和遗传学特征,以及治疗反应。基因工程小鼠(GEM)模型为揭示黑色素瘤发生发展和耐药性的关键分子机制提供了强大工具。在此,我们简要阐述小鼠建模设计的基础、可用的基因工程技术,以及影响使用GEMs对黑色素瘤进行建模的因素。此外,我们详细描述了目前可用的黑色素瘤GEM模型。《癌症》2017年;123:2089 - 103。© 2017美国癌症协会。