• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

急性慢性肝衰竭动物模型的前景：一篇综述。

Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review.

作者信息

Hassan Hozeifa Mohamed, Li Jun

机构信息

Precision Medicine Center, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

出版信息

J Clin Transl Hepatol. 2022 Oct 28;10(5):995-1003. doi: 10.14218/JCTH.2022.00086. Epub 2022 Apr 28.

DOI:10.14218/JCTH.2022.00086
PMID:36304511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9547251/
Abstract

Acute-on-chronic liver failure (ACLF) is a clinical syndrome that develops in patients with chronic liver diseases following a precipitating event and associated with a high mortality rate due to systemic multiorgan failure. Establishing a suitable and stable animal model to precisely elucidate the molecular basis of ACLF pathogenesis is essential for the development of effective early diagnostic and treatment strategies. In this context, this article provides a concise and inclusive review of breakthroughs in ACLF animal model development.

摘要

慢加急性肝衰竭（ACLF）是一种临床综合征，发生于慢性肝病患者在诱发事件之后，并因全身多器官衰竭而具有高死亡率。建立合适且稳定的动物模型以精确阐明ACLF发病机制的分子基础对于开发有效的早期诊断和治疗策略至关重要。在此背景下，本文对ACLF动物模型开发的突破进行了简明且全面的综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e7/9547251/44fab4bc0623/JCTH-10-0995-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e7/9547251/44fab4bc0623/JCTH-10-0995-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e7/9547251/44fab4bc0623/JCTH-10-0995-g001.jpg

相似文献

1
Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review.急性慢性肝衰竭动物模型的前景：一篇综述。
J Clin Transl Hepatol. 2022 Oct 28;10(5):995-1003. doi: 10.14218/JCTH.2022.00086. Epub 2022 Apr 28.
2
Acute-on-chronic liver failure in cirrhosis.肝硬化相关慢加急性肝衰竭。
Nat Rev Dis Primers. 2016 Jun 9;2:16041. doi: 10.1038/nrdp.2016.41.
3
Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis.急性慢性肝衰竭是一种独特的综合征，发生在肝硬化急性失代偿的患者中。
Gastroenterology. 2013 Jun;144(7):1426-37, 1437.e1-9. doi: 10.1053/j.gastro.2013.02.042. Epub 2013 Mar 6.
4
Acute-on-chronic liver failure (ACLF) in 2022: have novel treatment paradigms already arrived?2022 年急性慢性肝衰竭：新的治疗模式已经出现了吗？
Expert Rev Gastroenterol Hepatol. 2022 Jul;16(7):639-652. doi: 10.1080/17474124.2022.2097070. Epub 2022 Jul 7.
5
Acute on chronic liver failure: definitions, treatments and outcomes.慢性肝病急性肝衰竭：定义、治疗及转归
Curr Opin Gastroenterol. 2016 May;32(3):172-81. doi: 10.1097/MOG.0000000000000265.
6
Preoperative TIPS prevents the development of postoperative acute-on-chronic liver failure in patients with high CLIF-C AD score.术前经颈静脉肝内门体分流术可预防CLIF-C AD评分高的患者术后发生急性慢性肝衰竭。
JHEP Rep. 2022 Jan 21;4(3):100442. doi: 10.1016/j.jhepr.2022.100442. eCollection 2022 Mar.
7
Development and validation of a dynamic survival prediction model for patients with acute-on-chronic liver failure.急性慢性肝衰竭患者动态生存预测模型的开发与验证
JHEP Rep. 2021 Sep 29;3(6):100369. doi: 10.1016/j.jhepr.2021.100369. eCollection 2021 Dec.
8
Metabolomics profiles in acute-on-chronic liver failure: Unveiling pathogenesis and predicting progression.慢性肝衰竭急性发作的代谢组学特征：揭示发病机制与预测病情进展
Front Pharmacol. 2022 Aug 19;13:953297. doi: 10.3389/fphar.2022.953297. eCollection 2022.
9
Risk of different precipitating events for progressing to acute-on-chronic liver failure in HBV-related cirrhotic patients.乙肝相关肝硬化患者进展为慢加急性肝衰竭的不同诱发事件风险。
J Dig Dis. 2017 May;18(5):292-301. doi: 10.1111/1751-2980.12480.
10
Acute-on-chronic liver failure: a new clinical entity.急性慢性肝衰竭：一种新的临床实体。
Clin Gastroenterol Hepatol. 2015 May;13(5):836-41. doi: 10.1016/j.cgh.2014.02.027. Epub 2014 Feb 28.

引用本文的文献

1
Nothing but NET: A Novel Model of Alcohol Induced Acute-on-Chronic Liver Failure Demonstrates Both Enhanced Mechanistic Insight and a Possible Therapeutic Pathway.唯有中性粒细胞胞外诱捕网：酒精性急性-on-慢性肝衰竭的一种新模型展现了更强的机制性见解及一条可能的治疗途径。
Cell Mol Gastroenterol Hepatol. 2025;19(4):101455. doi: 10.1016/j.jcmgh.2024.101455. Epub 2025 Jan 17.
2
Ethanol Extract of the Microalga Shows Hepatoprotective Effects against Acetaminophen-Induced Acute Liver Injury in Mice.微藻的乙醇提取物对乙酰氨基酚诱导的小鼠急性肝损伤具有保护作用。
Int J Mol Sci. 2024 Jun 6;25(11):6247. doi: 10.3390/ijms25116247.
3

本文引用的文献

1
High-fat diet-induced increases in glucocorticoids contribute to the development of non-alcoholic fatty liver disease in mice.高脂肪饮食诱导的糖皮质激素增加导致小鼠非酒精性脂肪肝病的发生。
FASEB J. 2022 Jan;36(1):e22130. doi: 10.1096/fj.202101570R.
2
Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in rats.转录组学揭示了大鼠慢加急性肝衰竭中的免疫代谢紊乱。
Life Sci Alliance. 2021 Dec 1;5(3). doi: 10.26508/lsa.202101189. Print 2022 Mar.
3
The Jieduan-Niwan (JDNW) Formula Ameliorates Hepatocyte Apoptosis: A Study of the Inhibition of E2F1-Mediated Apoptosis Signaling Pathways in Acute-on-Chronic Liver Failure (ACLF) Using Rats.
Thrombospondin 1 enhances systemic inflammation and disease severity in acute-on-chronic liver failure.
血小板反应蛋白 1 增强慢加急性肝衰竭的全身炎症和疾病严重程度。
BMC Med. 2024 Mar 5;22(1):95. doi: 10.1186/s12916-024-03318-x.
截根逆挽方通过抑制 E2F1 介导的细胞凋亡信号通路改善慢加急性肝衰竭大鼠肝细胞凋亡
Drug Des Devel Ther. 2021 Sep 8;15:3845-3862. doi: 10.2147/DDDT.S308713. eCollection 2021.
4
Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models.肝硬化患者的肝外手术显著增加临床前动物模型的门静脉压力。
Front Physiol. 2021 Aug 20;12:720898. doi: 10.3389/fphys.2021.720898. eCollection 2021.
5
Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure.线粒体功能障碍调控急性肝衰竭患者白细胞的免疫代谢。
J Hepatol. 2022 Jan;76(1):93-106. doi: 10.1016/j.jhep.2021.08.009. Epub 2021 Aug 25.
6
Establishment of a murine model of acute-on-chronic liver failure with multi-organ dysfunction.建立具有多器官功能障碍的慢性肝衰竭急性加重的小鼠模型。
Hepatol Int. 2021 Dec;15(6):1389-1401. doi: 10.1007/s12072-021-10244-0. Epub 2021 Aug 25.
7
Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury.成纤维细胞生长因子21在慢性肝损伤急性发作临床前酒精模型中的反应
Int J Mol Sci. 2021 Jul 23;22(15):7898. doi: 10.3390/ijms22157898.
8
Animal Models for the Study of Hepatitis B Virus Pathobiology and Immunity: Past, Present, and Future.用于研究乙型肝炎病毒病理生物学和免疫的动物模型：过去、现在与未来
Front Microbiol. 2021 Jul 16;12:715450. doi: 10.3389/fmicb.2021.715450. eCollection 2021.
9
Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro.益七健脾方通过抑制缺氧损伤和凋亡来调节 PI3K/AKT 信号通路，减轻体内外慢性肝衰竭。
J Ethnopharmacol. 2021 Nov 15;280:114411. doi: 10.1016/j.jep.2021.114411. Epub 2021 Jul 12.
10
Human umbilical cord-derived mesenchymal stem cells improve the function of liver in rats with acute-on-chronic liver failure via downregulating Notch and Stat1/Stat3 signaling.人脐带间充质干细胞通过下调 Notch 和 Stat1/Stat3 信号改善慢性肝衰竭大鼠肝损伤。
Stem Cell Res Ther. 2021 Jul 13;12(1):396. doi: 10.1186/s13287-021-02468-6.