Bjornstrup Libana Raffoul, Reibel Jesper, Kiss Katalin, Schioedt Morten
DDS, Resident in Oral & Maxillofacial Surgery, Rigshospitalet Copenhagen, Copenhagen, Denmark.
Department of Oral Pathology, University of Copenhagen, Copenhagen, Denmark.
APMIS. 2017 Oct;125(10):933-936. doi: 10.1111/apm.12710. Epub 2017 May 25.
NUT carcinomas (NC) are rare and aggressive tumours characterized by chromosomal rearrangements of the gene encoding for nuclear protein of the testis (NUT) located on chromosome 15q14. This article presents a case of a 60-year-old woman diagnosed with NC presenting as a fast growing primary tumour in the right palate. Further evaluation revealed a tumour mass in the lungs and widespread metastases. A review of the literature did not reveal earlier cases presenting in the palate. In order to improve early diagnosis it is suggested to perform immunohistochemical testing for NUT in all poorly differentiated carcinomas without glandular differentiation arising in the chest, and head and neck (Clin Cancer Res, 18, 2012, 5773).
NUT癌（NC）是一种罕见的侵袭性肿瘤，其特征是位于15号染色体q14区域的编码睾丸核蛋白（NUT）的基因发生染色体重排。本文报告了一例60岁女性被诊断为NC的病例，该肿瘤表现为右腭部快速生长的原发性肿瘤。进一步评估发现肺部有肿瘤肿块及广泛转移。文献回顾未发现腭部出现更早病例。为了提高早期诊断率，建议对胸部、头颈部出现的所有无腺性分化的低分化癌进行NUT免疫组化检测（《临床癌症研究》，18卷，2012年，第5773页）。
