Niu H, Alvarez-Alvarez I, Guillen-Grima F, Al-Rahamneh M J, Aguinaga-Ontoso I
Department of Health Sciences, Public University of Navarre, Pamplona, Navarre.
Navarre's Institute for Health Research (IDISNA), Pamplona, Navarre.
Eur J Neurol. 2017 Jun;24(6):858-866. doi: 10.1111/ene.13302.
In many countries, Alzheimer's disease (AD) has gradually become a common disease in elderly populations. The aim of this study was to analyse trends of mortality caused by AD in the 28 member countries in the European Union (EU) over the last two decades.
We extracted data for AD deaths for the period 1994-2013 in the EU from the Eurostat and World Health Organization database. Age-standardized mortality rates per 100 000 were computed. Joinpoint regression was used to analyse the trends and compute the annual percent change in the EU as a whole and by country. Analyses by gender and by European regions were conducted.
Mortality from AD has risen in the EU throughout the study period. Most of the countries showed upward trends, with the sharpest increases in Slovakia, Lithuania and Romania. We recorded statistically significant increases of 4.7% and 6.0% in mortality rates in men and women, respectively, in the whole EU. Several countries showed changing trends during the study period. According to the regional analysis, northern and eastern countries showed the steepest increases, whereas in the latter years mortality has declined in western countries.
Our findings provide evidence that AD mortality has increased in the EU, especially in eastern and northern European countries and in the female population. Our results could be a reference for the development of primary prevention policies.
在许多国家，阿尔茨海默病（AD）已逐渐成为老年人群中的常见疾病。本研究旨在分析过去二十年欧盟（EU）28个成员国中由AD导致的死亡率趋势。
我们从欧盟统计局和世界卫生组织数据库中提取了1994 - 2013年期间欧盟AD死亡数据。计算了每10万人的年龄标准化死亡率。采用Joinpoint回归分析趋势，并计算整个欧盟及各成员国的年度百分比变化。进行了按性别和欧洲地区的分析。
在整个研究期间，欧盟AD死亡率呈上升趋势。大多数国家呈上升趋势，斯洛伐克、立陶宛和罗马尼亚的增幅最为显著。我们记录到，整个欧盟男性和女性的死亡率分别有4.7%和6.0%的统计学显著增长。几个国家在研究期间呈现出变化趋势。根据地区分析，北欧和东欧国家的增幅最为显著，而在后期，西方国家的死亡率有所下降。
我们的研究结果表明，欧盟AD死亡率有所上升，尤其是在北欧和东欧国家以及女性人群中。我们的结果可为初级预防政策的制定提供参考。
