Institute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090 V, ienna, Austria.
Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12416-12423. doi: 10.1002/anie.201702937. Epub 2017 Aug 30.
The synthesis of α-amino carbonyl compounds is an important challenge in synthesis en route to biologically essential structures. While classical approaches involve the use of enol or enolate chemistries in combination with an electrophilic source of nitrogen, those strategies usually necessitate further transformations to reach the desired targets. In recent years, a new approach arose involving the direct use of nucleophilic sources of nitrogen along with an oxidant. This approach advantageously leads, in one-pot, to the biologically relevant α-amino compound without requiring further transformation. This review highlights the recent advances in the emerging field of oxidative α-amination reactions using nucleophilic sources of nitrogen.
α-氨基羰基化合物的合成是生物必需结构合成途径中的一个重要挑战。虽然经典方法涉及使用烯醇或烯醇化物化学与亲电氮源结合，但这些策略通常需要进一步的转化才能达到所需的目标。近年来，出现了一种新的方法，涉及直接使用亲核氮源和氧化剂。这种方法有利地导致了生物相关的α-氨基化合物，而不需要进一步的转化。本文综述了使用亲核氮源的新兴氧化α-胺化反应领域的最新进展。
