Lephart Edwin D
Department of Physiology and Developmental Biology, The Neuroscience Center, Brigham Young University, Provo, UT, USA.
J Cosmet Dermatol. 2018 Apr;17(2):244-245. doi: 10.1111/jocd.12362. Epub 2017 May 25.
Many cosmetic companies utilize in vitro gene array studies to display significant stimulation or inhibition of various human skin biomarkers to validate in vivo actions that are reported to enhance dermal health. This follows the central dogma of DNA-to-RNA results in protein expression; however, gene and protein expressions do not usually correlate. Unless both gene and protein expressions are quantified which require further investigational time and investment. Where data are available, this short commentary displays the in vitro comparison of four human skin biomarkers for the gene and protein expressions of the stimulation of collagen type I and elastin and the inhibition of matrix metalloproteinases 1 and 3, when equol was tested. The results demonstrate a good correspondence between gene and protein expressions for the human skin biomarkers tested.
许多化妆品公司利用体外基因阵列研究来显示对各种人类皮肤生物标志物的显著刺激或抑制作用，以验证据报道可增强皮肤健康的体内作用。这遵循了DNA到RNA导致蛋白质表达的中心法则；然而，基因和蛋白质表达通常并不相关。除非对基因和蛋白质表达都进行定量，而这需要更多的研究时间和投入。在有数据的情况下，本简短评论展示了在测试雌马酚时，四种人类皮肤生物标志物在基因和蛋白质表达方面对I型胶原蛋白和弹性蛋白刺激以及基质金属蛋白酶1和3抑制的体外比较。结果表明，所测试的人类皮肤生物标志物的基因和蛋白质表达之间具有良好的对应关系。
