Moyron Ron B, Gonda Amber, Selleck Matthew J, Luo-Owen Xian, Catalano Richard D, O'Callahan Thomas, Garberoglio Carlos, Turay David, Wall Nathan R
Center for Health Disparities Research and Molecular Medicine, Loma Linda University, Loma Linda, CA, USA.
Department of Basic Sciences, Division of Biochemistry, Loma Linda University, Loma Linda, CA, USA.
Proteomics Clin Appl. 2017 Sep;11(9-10). doi: 10.1002/prca.201700061. Epub 2017 Jul 10.
Traumatic brain injuries (TBI) are among the most misdiagnosed and underreported types of head trauma. The potential long-term impact of undiagnosed or incorrectly identified concussions and other head injuries are potentially devastating, as evidenced by the increasing societal burden exhibited by soldiers returning from combat and athletes in contact sports. Concussions and TBI are notoriously difficult to correctly diagnose and prognosis for these injuries is poorly understood. In order to increase the likelihood of successful diagnosis, treatment, and prediction of outcomes, a definitive differential diagnosis will need to be established. The establishment of a "trauma-specific profile" or a panel of known trauma markers will significantly aid in this goal. Small membrane vesicles called exosomes have been shown to contain proteins and injury-specific biomarkers. In the future it is possible that they could become an important tool, utilized for their diagnostic and therapeutic potential.
创伤性脑损伤（TBI）是头部创伤中误诊率最高且报告不足的类型之一。未被诊断或错误识别的脑震荡和其他头部损伤的潜在长期影响可能是毁灭性的，从 combat 返回的士兵和从事接触性运动的运动员所表现出的日益增加的社会负担就可以看出这一点。脑震荡和 TBI notoriously难以正确诊断，而且对这些损伤的预后了解甚少。为了提高成功诊断、治疗和预测结果的可能性，需要建立明确的鉴别诊断。建立一个“创伤特异性概况”或一组已知的创伤标志物将大大有助于实现这一目标。被称为外泌体的小膜泡已被证明含有蛋白质和损伤特异性生物标志物。未来，它们有可能因其诊断和治疗潜力而成为一种重要工具。
