透明隔腔与首发精神病：一项荟萃分析。
Cavum septum pellucidum and first-episode psychosis: A meta-analysis.
作者信息
Liu Hanwen, Li Ling, Shen Li, Wang Xianliang, Hou Yazhu, Zhao Zhiqiang, Gu Lili, Mao Jingyuan
机构信息
Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Internal Medicine Unit, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
出版信息
PLoS One. 2017 May 17;12(5):e0177715. doi: 10.1371/journal.pone.0177715. eCollection 2017.
OBJECTIVES
To investigate the prevalence and changes of cavum septum pellucidum (CSP) in first-episode psychosis (FEP) patients.
METHODS
Medline, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched to identify eligible studies comparing FEP patients and healthy controls from inception to Feb 29, 2016.
RESULTS
Ten cross-sectional studies and three longitudinal studies reported in ten articles met our criteria. Our meta-analysis found no significant differences in the prevalence of either "any CSP" (OR = 1.41; 95% CI 0.90-2.20; p = 0.13; I2 = 52.7%) or "large CSP" (OR = 1.10; 95% CI 0.77-1.58; p = 0.59; I2 = 24.1%) between FEP patients and healthy controls. However, the heterogeneity analysis of the prevalence of "any CSP" suggested bias in outcome reporting.
CONCLUSIONS
The results based on current evidence suggest it is unclear whether "any CSP" is a risk factor for FEP due to the heterogeneity of the studies. There is insufficient evidence to support that "large CSP" is a possible risk factor for FEP.
目的
调查首发精神病（FEP）患者透明隔腔（CSP）的患病率及变化情况。
方法
检索Medline、Embase和Cochrane对照试验中央注册库（CENTRAL），以识别从起始至2016年2月29日比较FEP患者与健康对照的符合条件的研究。
结果
十篇文章中报道的十项横断面研究和三项纵向研究符合我们的标准。我们的荟萃分析发现，FEP患者与健康对照之间，“任何CSP”（比值比[OR]=1.41；95%可信区间[CI]0.90 - 2.20；p = 0.13；I² = 52.7%）或“大CSP”（OR = 1.10；95% CI 0.77 - 1.58；p = 0.59；I² = 24.1%）的患病率均无显著差异。然而，“任何CSP”患病率的异质性分析表明结果报告存在偏倚。
结论
基于当前证据的结果表明，由于研究的异质性，尚不清楚“任何CSP”是否为FEP的危险因素。没有足够的证据支持“大CSP”是FEP的可能危险因素。
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