• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

透明隔腔与首发精神病：一项荟萃分析。

Cavum septum pellucidum and first-episode psychosis: A meta-analysis.

作者信息

Liu Hanwen, Li Ling, Shen Li, Wang Xianliang, Hou Yazhu, Zhao Zhiqiang, Gu Lili, Mao Jingyuan

机构信息

Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Internal Medicine Unit, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

出版信息

PLoS One. 2017 May 17;12(5):e0177715. doi: 10.1371/journal.pone.0177715. eCollection 2017.

DOI:10.1371/journal.pone.0177715
PMID:28545119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5435239/
Abstract

OBJECTIVES

To investigate the prevalence and changes of cavum septum pellucidum (CSP) in first-episode psychosis (FEP) patients.

METHODS

Medline, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched to identify eligible studies comparing FEP patients and healthy controls from inception to Feb 29, 2016.

RESULTS

Ten cross-sectional studies and three longitudinal studies reported in ten articles met our criteria. Our meta-analysis found no significant differences in the prevalence of either "any CSP" (OR = 1.41; 95% CI 0.90-2.20; p = 0.13; I2 = 52.7%) or "large CSP" (OR = 1.10; 95% CI 0.77-1.58; p = 0.59; I2 = 24.1%) between FEP patients and healthy controls. However, the heterogeneity analysis of the prevalence of "any CSP" suggested bias in outcome reporting.

CONCLUSIONS

The results based on current evidence suggest it is unclear whether "any CSP" is a risk factor for FEP due to the heterogeneity of the studies. There is insufficient evidence to support that "large CSP" is a possible risk factor for FEP.

摘要

目的

调查首发精神病（FEP）患者透明隔腔（CSP）的患病率及变化情况。

方法

检索Medline、Embase和Cochrane对照试验中央注册库（CENTRAL），以识别从起始至2016年2月29日比较FEP患者与健康对照的符合条件的研究。

结果

十篇文章中报道的十项横断面研究和三项纵向研究符合我们的标准。我们的荟萃分析发现，FEP患者与健康对照之间，“任何CSP”（比值比[OR]=1.41；95%可信区间[CI]0.90 - 2.20；p = 0.13；I² = 52.7%）或“大CSP”（OR = 1.10；95% CI 0.77 - 1.58；p = 0.59；I² = 24.1%）的患病率均无显著差异。然而，“任何CSP”患病率的异质性分析表明结果报告存在偏倚。

结论

基于当前证据的结果表明，由于研究的异质性，尚不清楚“任何CSP”是否为FEP的危险因素。没有足够的证据支持“大CSP”是FEP的可能危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/eb2c39586597/pone.0177715.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/56850d7172f6/pone.0177715.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/80b862288171/pone.0177715.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/24d5033cf45e/pone.0177715.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/ca1f5e221655/pone.0177715.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/e98609bedd79/pone.0177715.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/f99d8819b4ec/pone.0177715.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/3c48fde23b48/pone.0177715.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/912b5b9759dc/pone.0177715.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/f5751b1be8fe/pone.0177715.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/eb2c39586597/pone.0177715.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/56850d7172f6/pone.0177715.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/80b862288171/pone.0177715.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/24d5033cf45e/pone.0177715.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/ca1f5e221655/pone.0177715.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/e98609bedd79/pone.0177715.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/f99d8819b4ec/pone.0177715.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/3c48fde23b48/pone.0177715.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/912b5b9759dc/pone.0177715.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/f5751b1be8fe/pone.0177715.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b3/5435239/eb2c39586597/pone.0177715.g010.jpg

相似文献

1
Cavum septum pellucidum and first-episode psychosis: A meta-analysis.透明隔腔与首发精神病：一项荟萃分析。
PLoS One. 2017 May 17;12(5):e0177715. doi: 10.1371/journal.pone.0177715. eCollection 2017.
2
Longitudinal follow-up of cavum septum pellucidum and adhesio interthalamica alterations in first-episode psychosis: a population-based MRI study.首发精神病患者透明隔腔和透明隔间腔黏连改变的纵向随访：一项基于人群的 MRI 研究。
Psychol Med. 2012 Dec;42(12):2523-34. doi: 10.1017/S0033291712000839. Epub 2012 Apr 27.
3
The Prevalence of Cavum Septum Pellucidum in Mental Disorders Revealed by MRI: A Meta-Analysis.MRI显示精神障碍中透明隔腔的患病率：一项荟萃分析
J Neuropsychiatry Clin Neurosci. 2020 Spring;32(2):175-184. doi: 10.1176/appi.neuropsych.18030060. Epub 2019 Jul 3.
4
Are cavum septum pellucidum abnormalities more common in schizophrenia spectrum disorders? A systematic review and meta-analysis.透明隔腔异常在精神分裂症谱系障碍中更常见吗？系统评价和荟萃分析。
Schizophr Res. 2011 Jan;125(1):1-12. doi: 10.1016/j.schres.2010.09.016. Epub 2010 Oct 20.
5
Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disorders.超高风险个体和精神障碍患者中透明隔腔增大的患病率。
Schizophr Res. 2008 Oct;105(1-3):236-44. doi: 10.1016/j.schres.2008.06.021. Epub 2008 Aug 6.
6
Cavum septum pellucidum in subjects at ultra-high risk for psychosis: compared with first-degree relatives of patients with schizophrenia and healthy volunteers.超高精神分裂症风险受试者的透明隔腔：与精神分裂症患者一级亲属及健康志愿者的比较
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1326-30. doi: 10.1016/j.pnpbp.2008.04.011. Epub 2008 Apr 22.
7
Midline Brain Abnormalities Across Psychotic and Mood Disorders.精神病性障碍和心境障碍中的中线脑异常
Schizophr Bull. 2016 Jan;42(1):229-38. doi: 10.1093/schbul/sbv097. Epub 2015 Jul 17.
8
Magnetic resonance imaging study of the cavum septi pellucidi in patients with schizophrenia.精神分裂症患者透明隔腔的磁共振成像研究。
Am J Psychiatry. 2001 Oct;158(10):1717-9. doi: 10.1176/appi.ajp.158.10.1717.
9
Increased prevalence of the cavum septum pellucidum in magnetic resonance scans and post-mortem brains of schizophrenic patients.精神分裂症患者磁共振扫描及尸检大脑中透明隔腔患病率增加。
Psychiatry Res. 1992 May;45(1):1-13. doi: 10.1016/0925-4927(92)90009-s.
10
Cavum septum pellucidum in schizophrenia, affective disorder and healthy controls: a magnetic resonance imaging study.精神分裂症、情感障碍及健康对照者的透明隔腔：一项磁共振成像研究
Psychol Med. 1993 May;23(2):319-22. doi: 10.1017/s0033291700028403.

引用本文的文献

1
Enlarged cavum septum pellucidum as a neuroimaging signature of head impact exposure.透明隔腔扩大作为头部撞击暴露的神经影像学特征。
Brain Commun. 2025 Feb 21;7(2):fcaf085. doi: 10.1093/braincomms/fcaf085. eCollection 2025.
2
The relationship between cavum septum pellucidum and psychopathic traits in a large forensic sample.在一个大型法医样本中，透明隔腔与精神变态特征之间的关系。
Neuropsychologia. 2018 Apr;112:95-104. doi: 10.1016/j.neuropsychologia.2018.03.015. Epub 2018 Mar 12.

本文引用的文献

1
Diagnostic Stability of ICD/DSM First Episode Psychosis Diagnoses: Meta-analysis.国际疾病分类/精神疾病诊断与统计手册首次发作精神病诊断的诊断稳定性：荟萃分析
Schizophr Bull. 2016 Nov;42(6):1395-1406. doi: 10.1093/schbul/sbw020. Epub 2016 Mar 15.
2
Midline Brain Abnormalities Across Psychotic and Mood Disorders.精神病性障碍和心境障碍中的中线脑异常
Schizophr Bull. 2016 Jan;42(1):229-38. doi: 10.1093/schbul/sbv097. Epub 2015 Jul 17.
3
What determines continuing grey matter changes in first-episode schizophrenia and affective psychosis?
首发精神分裂症和情感性精神病中持续灰质变化的决定因素是什么？
Psychol Med. 2015 Mar;45(4):817-28. doi: 10.1017/S0033291714001895. Epub 2014 Sep 2.
4
The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects.精神分裂症患者中 DISC1 Ser704Cys 多态性与脑神经发育标志物的研究。
Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jan 2;56:11-7. doi: 10.1016/j.pnpbp.2014.07.005. Epub 2014 Aug 1.
5
Enlarged cavum septum pellucidum as a neurodevelopmental marker in adolescent-onset opiate dependence.透明隔腔扩大可作为青少年发病型阿片类药物依赖的神经发育标志物。
PLoS One. 2013 Oct 24;8(10):e78590. doi: 10.1371/journal.pone.0078590. eCollection 2013.
6
Longitudinal MRI study of the midline brain regions in first-episode schizophrenia.首发精神分裂症患者脑中线区域的纵向 MRI 研究。
Psychiatry Res. 2013 May 30;212(2):150-3. doi: 10.1016/j.pscychresns.2012.12.001. Epub 2013 Mar 28.
7
Longitudinal follow-up of cavum septum pellucidum and adhesio interthalamica alterations in first-episode psychosis: a population-based MRI study.首发精神病患者透明隔腔和透明隔间腔黏连改变的纵向随访：一项基于人群的 MRI 研究。
Psychol Med. 2012 Dec;42(12):2523-34. doi: 10.1017/S0033291712000839. Epub 2012 Apr 27.
8
Association of grey matter volume deviation with insight impairment in first-episode affective and non-affective psychosis.首发情感性和非情感性精神病患者灰质体积偏差与洞察力损害的关联。
Eur Arch Psychiatry Clin Neurosci. 2013 Mar;263(2):133-41. doi: 10.1007/s00406-012-0333-8. Epub 2012 Jun 7.
9
An MRI study of septi pellucidi in relation to hippocampus volume and fornix integrity in schizophrenia.精神分裂症患者中软脑膜与海马体积和穹窿完整性的 MRI 研究。
Schizophr Res. 2012 Feb;134(2-3):165-70. doi: 10.1016/j.schres.2011.11.012. Epub 2011 Dec 16.
10
Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia.长期抗精神病药物治疗与脑容量：首发精神分裂症的纵向研究
Arch Gen Psychiatry. 2011 Feb;68(2):128-37. doi: 10.1001/archgenpsychiatry.2010.199.