2 型糖尿病是轻度认知障碍患者向痴呆转化的独立危险因素。
Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment.
机构信息
Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Spain.
Fundació ACE, Barcelona Alzheimer Treatment & Research Center, Barcelona, Spain.
出版信息
J Diabetes Complications. 2017 Aug;31(8):1272-1274. doi: 10.1016/j.jdiacomp.2017.04.018. Epub 2017 Apr 19.
AIMS
To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI).
METHODS
A longitudinal nested case-control study in which 101 T2D patients and 101 non-diabetic patients with MCI matched by age and gender were included.
RESULTS
The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p=0.02). T2D and APOE ε4 allele were independent risk factors for developing dementia.
CONCLUSION
T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications.
目的
探讨 2 型糖尿病（T2D）是否是轻度认知障碍（MCI）患者发生痴呆转化的危险因素。
方法
这是一项纵向巢式病例对照研究，纳入了 101 例 T2D 患者和 101 例年龄和性别相匹配的非糖尿病 MCI 患者。
结果
T2D 患者的痴呆转化率为 57.4%，而非糖尿病患者为 42.6%（p=0.02）。T2D 和 APOE ε4 等位基因是发生痴呆的独立危险因素。
结论
T2D 是 MCI 患者痴呆转化的独立危险因素。这一发现具有重要的临床意义。
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