Sauder D N, Arsenault T, McKenzie R C, Stetsko D K, Harley C B
Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada.
Ann N Y Acad Sci. 1988;548:241-52. doi: 10.1111/j.1749-6632.1988.tb18812.x.
ETAF/IL-1 has a multiplicity of divergent biological effects: enhancement of thymocyte proliferation, stimulation of cells in the hypothalamus to mediate fever, leukocyte chemotaxis, stimulation of hepatic synthesis of acute-phase proteins, augmentation of IL-2 production and keratinocyte proliferation. Until recently, it has not been possible to determine whether these divergent activities are mediated by closely related cytokines or separate cytokines. Now with the identification of IL-1 alpha, IL-1 beta and IL-1k from keratinocytes, these studies will become possible. In either case, it is likely that ETAF/IL-1 plays an important role in local cutaneous and systemic inflammatory and immunological events.
内源性热原质/白细胞介素-1具有多种不同的生物学效应：增强胸腺细胞增殖、刺激下丘脑细胞介导发热、白细胞趋化作用、刺激肝脏合成急性期蛋白、增强白细胞介素-2的产生以及角质形成细胞增殖。直到最近，尚无法确定这些不同的活性是由密切相关的细胞因子还是单独的细胞因子介导的。现在随着角质形成细胞中白细胞介素-1α、白细胞介素-1β和白细胞介素-1κ的鉴定，这些研究将成为可能。无论哪种情况，内源性热原质/白细胞介素-1可能在局部皮肤和全身炎症及免疫事件中起重要作用。
