Coppes O J Michael, Sang Christine N
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Translational Pain Research, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Curr Pain Headache Rep. 2017 Jun;21(6):30. doi: 10.1007/s11916-017-0630-z.
As opioids have become more common in clinical practice for the treatment of both acute and chronic pain, so too has the need for a deeper understanding of the clinical applications of opioid antagonists. The purpose of this review is to present both the longstanding and potential new indications for the use of drugs that block the effects of opioid receptors.
There is a growing body of data demonstrating the modulation of pain by opioid antagonists. Additional clinical studies that show their direct antinociceptive effects and/or enhancement of the analgesic potency of opioid agonists are warranted. We briefly discuss the well-established role that these agents play in the reversal of life-threatening opioid toxicity and explore both existing and expanding clinical applications, including their apparent paradox that they may themselves be associated with analgesia.
随着阿片类药物在临床实践中越来越普遍地用于治疗急性和慢性疼痛，对阿片类拮抗剂临床应用的更深入理解也变得愈发必要。本综述的目的是介绍阻断阿片受体作用的药物的长期和潜在新适应症。
越来越多的数据表明阿片类拮抗剂可调节疼痛。有必要开展更多临床研究以显示其直接的抗伤害感受作用和/或增强阿片类激动剂的镇痛效力。我们简要讨论了这些药物在逆转危及生命的阿片类药物毒性方面已确立的作用，并探讨了现有的和不断扩展的临床应用，包括它们自身可能与镇痛相关这一明显的矛盾之处。
