Lee Robert J, Lindley Martin R, Pritchard Gareth J, Kimber Marc C
School of Science, Department of Chemistry, Loughborough University, Loughborough, LE11 3TU, UK.
Chem Commun (Camb). 2017 Jun 8;53(47):6327-6330. doi: 10.1039/c7cc03229c.
Appel reaction conditions have been harnessed to affect a mild biosynthetically inspired dehydration of endoperoxides to deliver multi-substituted electron rich furans. Unlike traditional dehydrative procedures, this method is metal and acid free, and can be achieved under redox neutral conditions. It is general for a range of aryl and alkyl substituted endoperoxides, and is functional group tolerant. Furthermore, this procedure has been used to deliver an effective total synthesis of the furan fatty acid (FFA) F.
阿佩尔反应条件已被用于实现一种温和的、受生物合成启发的内过氧化物脱水反应，以生成多取代的富电子呋喃。与传统的脱水方法不同，该方法无需金属和酸，且能在氧化还原中性条件下实现。它适用于一系列芳基和烷基取代的内过氧化物，并且对官能团具有耐受性。此外，该方法已被用于实现呋喃脂肪酸（FFA）F的有效全合成。
