纳洛酮疗效和安全性的药代动力学建模：对剂量和标签的影响。
Pharmacometric Modeling of Naloxegol Efficacy and Safety: Impact on Dose and Label.
机构信息
Quantitative Clinical Pharmacology, AstraZeneca LP, Waltham, Massachusetts, USA.
出版信息
Clin Pharmacol Ther. 2017 Nov;102(5):741-744. doi: 10.1002/cpt.719. Epub 2017 May 26.
DOI:10.1002/cpt.719
PMID:28548207
Abstract
Naloxegol is a peripherally acting μ-opioid receptor antagonist that was developed for the treatment of opioid-induced constipation. Modeling and simulation of naloxegol efficacy and tolerability informed selection of doses for phase III studies and provided comprehensive dosage recommendations for the naloxegol US package insert.
摘要
纳洛酮是一种外周作用的 μ 阿片受体拮抗剂，用于治疗阿片类药物引起的便秘。纳洛酮疗效和耐受性的建模和模拟为 III 期研究选择剂量提供了信息，并为纳洛酮美国说明书提供了全面的剂量建议。
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