血清 CYR61 与格雷夫斯眼病的疾病活动有关。
Serum CYR61 Is Associated with Disease Activity in Graves' Orbitopathy.
机构信息
a Institute of Vision Research, Department of Ophthalmology , Yonsei University College of Medicine , Seoul , South Korea.
b Department of Plastic Surgery, Yonsei First Plastic Surgery Clinic , Seoul , South Korea.
出版信息
Ocul Immunol Inflamm. 2018;26(7):1094-1100. doi: 10.1080/09273948.2017.1319960. Epub 2017 May 26.
PURPOSE
To investigate the clinical implications of cysteine-rich angiogenic inducer 61 (CYR61) in Graves' orbitopathy (GO).
METHODS
Sera from 52 GO patients, 23 Graves' disease (GD) patients, and 20 healthy controls, and orbital fat tissue samples from 12 of 52 GO patients and 8 control subjects were included for analysis. Concentrations of CYR61 were measured from sera with an enzyme-linked immunosorbent assay, and CYR61 mRNA expression levels were evaluated from orbital fat tissue with polymerase chain reaction.
RESULTS
Serum CYR61 levels were higher in GO patients than in controls (p = 0.001). Patients with active GO showed higher CYR61 levels than those with inactive GO (p < 0.001) or GD (p = 0.004). Expression of CYR61 mRNA was 7.4-fold higher in patients with GO than in healthy controls (p < 0.001).
CONCLUSIONS
CYR61 could be an adjuvant biomarker associated with the inflammatory activity of GO.
目的
探讨富含半胱氨酸的血管生成诱导因子 61（CYR61）在格雷夫斯眼病（GO）中的临床意义。
方法
纳入 52 例 GO 患者、23 例格雷夫斯病（GD）患者和 20 名健康对照者的血清，以及 52 例 GO 患者中的 12 例和 8 名对照者的眼眶脂肪组织样本进行分析。采用酶联免疫吸附试验（ELISA）检测血清中 CYR61 的浓度，采用聚合酶链反应（PCR）检测眼眶脂肪组织中 CYR61 mRNA 的表达水平。
结果
GO 患者的血清 CYR61 水平高于对照组（p=0.001）。活动期 GO 患者的 CYR61 水平高于非活动期 GO 患者（p<0.001）或 GD 患者（p=0.004）。GO 患者的 CYR61 mRNA 表达水平比健康对照组高 7.4 倍（p<0.001）。
结论
CYR61 可能是一种与 GO 炎症活动相关的辅助生物标志物。
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