a Ocular Immunology Department , School of Medicine, CES University , Medellín , Colombia.
b Immunology Department, School of Medicine and Health Sciences , Neuroscience Research Group, NeURos, Rosario University , Bogotá , Colombia.
Ocul Immunol Inflamm. 2018;26(7):1101-1106. doi: 10.1080/09273948.2017.1320411. Epub 2017 May 26.
To describe severe bilateral iris depigmentation and persistent ocular hypotony as end-stage manifestations of untreated Vogt-Koyanagi-Harada disease.
We present the clinical findings and diagnostic studies performed for three patients with bilateral iris depigmentation.
Vogt-Koyanagi-Harada disease in late recurrent stage was diagnosed in three patients with bilateral severe iris depigmentation and persistent ocular hypotony.
Early diagnosis and treatment of inflammation are crucial factors in the clinical outcome of Vogt-Koyanagi-Harada disease. When left undiagnosed and untreated from early stages, severe iris depigmentation and ocular hypotony, uncommon manifestations of this disease, can develop.
描述未经治疗的 Vogt-小柳原田病（Vogt-Koyanagi-Harada disease，VKH）晚期的严重双侧虹膜色素脱失和持续性低眼压，作为该病的终末表现。
我们介绍了 3 例双侧虹膜色素脱失患者的临床表现和诊断研究结果。
3 例双侧严重虹膜色素脱失和持续性低眼压患者被诊断为晚期复发性 Vogt-Koyanagi-Harada 病。
早期诊断和治疗炎症是 Vogt-Koyanagi-Harada 病临床转归的关键因素。如果在早期未被诊断和治疗，该病可能发展为罕见的严重虹膜色素脱失和低眼压等终末表现。
